Anti-TMEM119 Antibody (L128/43)

Name: Anti-TMEM119 Antibody
Brand: NeuroMab
SKU: 75-512
Price: 308.0 USD
Availability: InStock

from NeuroMab Datasheet

Trial Size

Available Conjugates

490

550

594

650

Product Type

Primary Antibody

Species Reactivity

Mouse

Clone

L128/43

Applications

ICC, IHC, WB

Host Species

Mouse

Format

Purified by Protein A chromatography

Gene Name

TMEM119

Molecular Weight

30 kDa

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Anti-TMEM119 Antibody

Volume: 100 µL

Variant

Price:

$308

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Product Details

Target

TMEM119, OBIF

Target Description

TMEM119, is a plasma membrane protein first identified because of its role in the differentiation of osteoblasts (Kanamoto et al., 2009). However TMEM119 is also known to be a specific marker of microglia, the tissue-resident macrophages of brain and spinal cord (Bennett et al., 2016). Unlike other microglia markers, TMEM119 expression readily distinguishes resident microglia from blood-derived macrophages, making it a highly specific microglia marker. In healthy brain microglia are the resident immune cells where they act to neutralize pathogens, clear dead and dying cells, and prune synaptic connections. However, in neurodegenerative disease microglia can actually promote neuronal degeneration through reduced phagocytic clearance and increased pro-inflammatory effects. Our anti-TMEM119 antibody is a highly specific microglial marker for mouse TMEM119 and works by western blot and immunocytochemistry.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

L128/43

Isotype

IgG1

Applications

ICC, IHC, WB

Host Species

Mouse

Gene Name

TMEM119

Molecular Weight

30 kDa

Antigen

Fusion protein amino acids 113-280 (cytoplasmic C-terminus) of mouse Tmem119

Species Reactivity

Mouse

Antibody Registry ID

AB_2927661

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125

Conjugate

Unconjugated

Specificity

No cross-reactivity reported

Quality Control

Each new lot of this antibody is tested to confirm that it shows the expected staining pattern when used to stain COS cells overexpressing target.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

TMEM119, OBIF

UniProt Details

UniProt (Immunogen Species): Q8R138

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Anti-TMEM119 Antibody (L128/43)

Available Conjugates

Anti-TMEM119 Antibody
SKU: 75-512

Bulk Order Anti-TMEM119 Antibody

Product Details

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Anti-TMEM119 Antibody (L128/43)

Available Conjugates

Anti-TMEM119 Antibody SKU: 75-512

Bulk Order Anti-TMEM119 Antibody

Product Details

Anti-TMEM119 Antibody
SKU: 75-512