Disks large-associated protein 3,SAP90/PSD-95-Associated Protein 3 or SAPAP3 is encoded by the gene DLGAP3 and is a member of the SAPAP or DLGAP family of proteins. SAPAP3 acts as a scaffold protein and is involved with glutamate receptor signaling. SAPAP3 is highly expressed in the central and peripheral nervous system. Within the cell, SAPAP3 is found at the postsynaptic density. Diseases associated with DLGAP3 include Trichotillomania and Body Dysmorphic Disorder.
ICC, IHC, WB
Fusion protein amino acids 790-977 (C-terminus) of mouse SAPAP3 (also known as Disks large- associated protein 3, PSD-95/SAP90-binding protein 3, SAP90/PSD-95 associated protein 3, Dlgap3 and Dap3, accession number Q6PFD5); Rat: 100% identity (188/188 amino acids identical); Human: 99% identity (186/188 amino acids identical); >60% identity with SAPAP2/DLGAP2 and other SAPAP/DLGAP proteins
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