Anti-Pan-Shank Antibody (N23B/49)

Name: Anti-Pan-Shank Antibody
Brand: NeuroMab
SKU: 75-089
Price: 295.0 USD
Availability: InStock

from NeuroMab Datasheet

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Clonality

Monoclonal

Applications

IHC, IP, WB

Host Species

Mouse

Gene Name

Shank1 Shank2 Cortbp1 Kiaa1022 PROSAP1 Shank3 Kiaa1650 Prosap2 PSAP2

Molecular Weight

160 kDa

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Cultured rat hippocampal neuron immunofluorescence: N23B/49 (Pan-Shank) = red, rabbit anti-PSD-95 = green, merge = yellow (bottom right). Image courtesy of Dr. Albert Hung, Picower Institute, MIT.

Adult rat hippocampus immunohistochemistry.

Transfected cell immunoblot: extracts of COS-1 cells transiently transfected with Shank1, Shank2 or Shank3 plasmids and probed with N23B/49 TC supe or a lane loading control.

Immunoblots on brain membranes prepared from whole rat (RBM) and mouse (MBM) brain, and from human cerebral cortex [HBM(Cx)] and hippocampus [HBM(H)].

Cultured rat hippocampal neuron immunofluorescence: N23B/49 (Pan-Shank) = red, rabbit anti-PSD-95 = green, merge = yellow (bottom right). Image courtesy of Dr. Albert Hung, Picower Institute, MIT.

Product Details

Target

Pan-Shank

Target Description

This antibody is a pan antibody that recognizes SH3 and multiple ankyrin repeat domains protein 1 (Shank 1), SH3 and multiple ankyrin repeat domains protein 2 (Shank 2) and SH3 and multiple ankyrin repeat domains protein 3 (Shank3). Shank proteins act as a scaffold protein anchoring and connecting membrane bound receptors and other proteins to the cytoskeleton in neurons to enable cell signaling.

Format

Purified

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N23B/49

Isotype

IgG1

Applications

IHC, IP, WB

Host Species

Mouse

Gene Name

Shank1 Shank2 Cortbp1 Kiaa1022 PROSAP1 Shank3 Kiaa1650 Prosap2 PSAP2

Molecular Weight

160 kDa

Antigen

Fusion protein amino acids 84-309 (SH3/PDZ domains) of rat Shank2 (accession number Q9QX74); Human: 94% identity (213/226 amino acids identical); Mouse: 97% identity (220/226 amino acids identical)

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_10672418

Storage

Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Buffer

10mM Tris, 50mM Sodium Chloride, 0.065 % Sodium Azide pH 7.4

Conjugate

Unconjugated

Specificity

Recognizes Shank1, Shank2 and Shank3

Quality Control

Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from opening

Synonyms

SH3 and multiple ankyrin repeat domains protein 1 (Shank1) (GKAP/SAPAP-interacting protein) (SPANK-1) (Somatostatin receptor-interacting protein) (SSTR-interacting protein) (SSTRIP) (Synamon) SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin-binding protein 1) (CortBP1) (GKAP/SAPAP-interacting protein) (Proline-rich synapse-associated protein 1) (ProSAP1) (SPANK-3) SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2) (SPANK-2)

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Anti-Pan-Shank Antibody (N23B/49)

Anti-Pan-Shank Antibody
SKU: 75-089

Product Details

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Anti-Pan-Shank Antibody (N23B/49)

Anti-Pan-Shank Antibody SKU: 75-089

Product Details

Anti-Pan-Shank Antibody
SKU: 75-089