Anti-Pan-Nav1 Sodium Channel Antibody (N419/78)

Name: Anti-Pan-Nav1 Sodium Channel Antibody
Brand: NeuroMab
SKU: 75-407
Price: 329.0 USD
Availability: InStock

4 Citations

Our Anti-Pan-Nav1 sodium channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N419/78. It detects human, mouse, and rat Pan-Nav1 sodium channel, and is purified by Protein A chromatography. It is great for use in IHC, ICC, WB.

$Immunoblot against fractions of adult rat brain membranes (RBM) and extracts of COS or HEK cells transiently or stably expressing different untagged Nav1.X or Kv2.1 plasmid probed with N419/40 (left) or K58/35 (right) TC supe.$

Immunoblot against fractions of adult rat brain membranes (RBM) and extracts of COS or HEK cells transiently or stably expressing different untagged Nav1.X or Kv2.1 plasmid probed with N419/40 (left) or K58/35 (right) TC supe.

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Species Reactivity

Human, Mouse, Rat

Applications

ICC, IHC, WB

Host Species

Mouse

Conjugates and Formulations

490

550

594

650

Carrier-Free

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Data Sheet

SKU: 75-407

Volume: 100 µL

Variant

Price:

$329.00

Quantity:

Ships: 1-2 business days

Product Details

Target

Pan-Nav1 sodium channel

Target Description

The family of voltage gated sodium channels comprise a large alpha subunit and auxiliary beta subunits. Nav1 channels are members of the voltage gated sodium ion channel family and form the alpha type, pore-forming subunit of the channel. There are nine known members of this family. These alpha subunits vary in their function and tissue expression.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N419/78

Isotype

IgG1

Applications

ICC, IHC, WB

Host Species

Mouse

Gene Name

SCN2A NAC2 SCN2A1 SCN2A2 SCN1A NAC1 SCN1 SCN9A NENA SCN5A SCN3A KIAA1356 NAC3 SCN8A MED SCN10A SCN4A SCN11A SCN12A SNS2

Molecular Weight

>200 kDa

Antigen

Synthetic peptide amino acids 1501-1518 (TEEQKKYYNAMKKLGSKK, cytoplasmic loop between repeat III and IV) of human Nav1.1 (accession number P35498)

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2493099

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125

Dilution Ranges

IHC: 1:250

Conjugate

Unconjugated

Specificity

Cross-reacts with multiple Nav1 channels

Quality Control

Each new lot of antibody is quality control tested on cells overexpressing target protein and confirmed to give the expected staining pattern.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Sodium channel protein type 2 subunit alpha (HBSC II) (Sodium channel protein brain II subunit alpha) (Sodium channel protein type II subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.2) Sodium channel protein type 1 subunit alpha (Sodium channel protein brain I subunit alpha) (Sodium channel protein type I subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.1) Sodium channel protein type 9 subunit alpha (Neuroendocrine sodium channel) (hNE-Na) (Peripheral sodium channel 1) (PN1) (Sodium channel protein type IX subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.7) Sodium channel protein type 5 subunit alpha (HH1) (Sodium channel protein cardiac muscle subunit alpha) (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) Sodium channel protein type 3 subunit alpha (Sodium channel protein brain III subunit alpha) (Sodium channel protein type III subunit alpha) (Voltage-gated sodium channel subtype III) (Voltage-gated sodium channel subunit alpha Nav1.3) Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6) Sodium channel protein type 10 subunit alpha (Peripheral nerve sodium channel 3) (PN3) (hPN3) (Sodium channel protein type X subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.8) Sodium channel protein type 4 subunit alpha (SkM1) (Sodium channel protein skeletal muscle subunit alpha) (Sodium channel protein type IV subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.4) Sodium channel protein type 11 subunit alpha (Peripheral nerve sodium channel 5) (PN5) (Sensory neuron sodium channel 2) (Sodium channel protein type XI subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.9)

UniProt ID

P35498

Product Specific References for Applications and Species

Immunohistochemistry: Mouse

Immunohistochemistry: Mouse
PMID	Dilution	Publication
34289389	not listed	Zhang, C., et al. 2021. Ankyrin-dependent Na+ channel clustering prevents neuromuscular synapse fatigue. Current Biology, 3810-3819.
34180393	1:250	Stevens, S.R., et al. 2021. Ankyrin-R regulates fast-spiking interneuron excitability through perineuronal nets and Kv3. 1b K+ channels. . Elife, e66491.
32425157	1:300	Liu, C.H., et al. 2020. β spectrin-dependent and domain specific mechanisms for Na + channel clustering. Elife, e56629.
32052742	1:300	Liu, C.H., et al. 2020. Nodal β spectrins are required to maintain Na + channel clustering and axon integrity. Elife, e52378.

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Anti-Pan-Nav1 Sodium Channel Antibody (N419/78)

SKU: 75-407

Product Details

Product Specific References for Applications and Species

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