Anti-Pan-MAGUK Antibody (K28/86)

Name: Anti-Pan-MAGUK Antibody
Brand: NeuroMab
SKU: 75-029
Price: 308.0 USD
Availability: InStock

from NeuroMab Datasheet

This antibody recognizes endogenous levels of DLG1/SAP97, DLG2/Chapsyn-110, DLG3/SAP102, and DLG4/PSD95 by western blot, immunoprecipitation, and immunocytochemistry.

Product Type

Primary Antibody

Species Reactivity

Human, Mouse, Rat, Xenopus, Zebrafish

Clone

K28/86

Applications

IP, WB

Host Species

Mouse

Format

Purified

Gene Name

DLG1 DLG2 DLG3 KIAA1232 DLG4 PSD95

Molecular Weight

95-110 kDa (varies with cell background due to phosphorylation)

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Immunoblot against crude C. elegans worm extracts and crude brain membranes from adult rat (RBM) probed with K28/86 TC supe.

$Immunoblot against crude membrane fractions from whole mouse (MBM) or rat (RBM) brain and from human cerebellum [HBM(Cb)], cerebral cortex [HBM(Cx)] or hippocampus [HBM(H)] probed with K28/86 (left) or N52A/42 (right) TC supe.$

Immunoblot against crude C. elegans worm extracts and crude brain membranes from adult rat (RBM) probed with K28/86 TC supe.

Volume: 100 µL

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Product Details

Target

Pan-MAGUK

Target Description

Membrane-associated guanylate kinases (MAGUKs) are a large family of scaffold proteins that play essential roles in tissue development, cell-cell communication, cell polarity control, and cellular signal transduction. MAGUKs act as key scaffolds in surface complexes containing receptors, adhesion proteins, and various signaling molecules and play key roles in cell-cell intercommunication. The neuronal synapse is a prime example of this, where the MAGUK proteins play a critical role in organizing both pre and post-synaptic proteins into functional assemblies. Major synaptic MAGUK proteins include PSD-95, SAP102, SAP97, PSD-93, CASK, and MAGIs. Together, they play roles in both synaptic development and in synaptic plasticity.

Format

Purified

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

K28/86

Isotype

IgG1

Applications

IP, WB

Host Species

Mouse

Gene Name

DLG1 DLG2 DLG3 KIAA1232 DLG4 PSD95

Molecular Weight

95-110 kDa (varies with cell background due to phosphorylation)

Antigen

Fusion protein amino acids 77-299 of human PSD-95/SAP90; Rat: 100% identity; Mouse=99% identity (221/223 amino acids)

Species Reactivity

Human, Mouse, Rat, Xenopus, Zebrafish

Antibody Registry ID

AB_10673115

Storage

Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Buffer

10mM Tris, 50mM Sodium Chloride, 0.065 % Sodium Azide pH 7.4

Conjugate

Unconjugated

Specificity

Exhibits cross-reactivity against recombinant Chapsyn-110, SAP97 and SAP102

Quality Control

Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from opening

Synonyms

Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (SAP97) (hDlg) Disks large homolog 2 (Channel-associated protein of synapse-110) (Chapsyn-110) (Postsynaptic density protein PSD-93) Disks large homolog 3 (Neuroendocrine-DLG) (Synapse-associated protein 102) (SAP-102) (SAP102) (XLMR) Disks large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP-90) (SAP90)

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Anti-Pan-MAGUK Antibody (K28/86)

This antibody recognizes endogenous levels of DLG1/SAP97, DLG2/Chapsyn-110, DLG3/SAP102, and DLG4/PSD95 by western blot, immunoprecipitation, and immunocytochemistry.

Anti-Pan-MAGUK Antibody
SKU: 75-029

Bulk Order Anti-Pan-MAGUK Antibody

Product Details

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Anti-Pan-MAGUK Antibody (K28/86)

This antibody recognizes endogenous levels of DLG1/SAP97, DLG2/Chapsyn-110, DLG3/SAP102, and DLG4/PSD95 by western blot, immunoprecipitation, and immunocytochemistry.

Anti-Pan-MAGUK Antibody SKU: 75-029

Bulk Order Anti-Pan-MAGUK Antibody

Product Details

Anti-Pan-MAGUK Antibody
SKU: 75-029