Immunoblot against crude C. elegans worm extracts and crude brain membranes from adult rat (RBM) probed with K28/86 TC supe.
Membrane-associated guanylate kinases (MAGUKs) are a large family of scaffold proteins that play essential roles in tissue development, cell-cell communication, cell polarity control, and cellular signal transduction. MAGUKs act as key scaffolds in surface complexes containing receptors, adhesion proteins, and various signaling molecules and play key roles in cell-cell intercommunication. The neuronal synapse is a prime example of this, where the MAGUK proteins play a critical role in organizing both pre and post-synaptic proteins into functional assemblies. Major synaptic MAGUK proteins include PSD-95, SAP102, SAP97, PSD-93, CASK, and MAGIs. Together, they play roles in both synaptic development and in synaptic plasticity.
DLG1 DLG2 DLG3 KIAA1232 DLG4 PSD95
95-110 kDa (varies with cell background due to phosphorylation)
Fusion protein amino acids 77-299 of human PSD-95/SAP90; Rat: 100% identity; Mouse=99% identity (221/223 amino acids)
Human, Mouse, Rat, Xenopus, Zebrafish
Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Exhibits cross-reactivity against recombinant Chapsyn-110, SAP97 and SAP102
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
24 months from opening
Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (SAP97) (hDlg) Disks large homolog 2 (Channel-associated protein of synapse-110) (Chapsyn-110) (Postsynaptic density protein PSD-93) Disks large homolog 3 (Neuroendocrine-DLG) (Synapse-associated protein 102) (SAP-102) (SAP102) (XLMR) Disks large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP-90) (SAP90)
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