Anti-NGL-2/LRRC4 Antibody (N50/36)

Name: Anti-NGL-2/LRRC4 Antibody
Brand: NeuroMab
SKU: 75-084
Price: 295.0 USD
Availability: InStock

from NeuroMab Datasheet KO Validated

3 Citations

Product Type

Primary Antibody

Species Reactivity

Mouse, Rat

Clone

N50/36

Applications

ICC, WB

Host Species

Mouse

Format

Purified

Gene Name

Lrrc4

Molecular Weight

100 kDa

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Adult rat brain membrane (RBM) and transfected cell immunoblot: extracts of RBM and COS cells transiently transfected with Myc-tagged NGL-1, NGL-2, NGL-3 or untagged Kv2.1 plasmid and probed with N50/36 (left) or K89/41 (right) TC supe.

Adult mouse brain immunoblot: extracts of brains from wild-type (1), Netrin-G2 knockout (2) and NGL-2 knockout (3) mice were probed with Netrin-G2 antibody (left) or N50/36 (right). Reproduced with permission from 2007 Zhang et al Genes Brain Behav.

Volume: 100 µL

Variant

Price:

$295

Quantity:

Bulk Order Anti-NGL-2/LRRC4 Antibody

Product Details

Target

NGL-2/LRRC4

Target Description

Leucine Rich Repeat Containing 4 is encoded by the gene LRRC4. LRRC4 is a synaptic adhesion protein that regulates the formation of excitatory synapses through the recruitment of pre and postsynaptic proteins. LRRC4 organizes the lamina pathway-specific differentiation of dendrites, and plays an important role in auditory synaptic responses. LRRC4 is expressed in the brain. LRRC4 is significantly downregulated in primary brain tumors.

Format

Purified

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N50/36

Isotype

IgG1

Applications

ICC, WB

Host Species

Mouse

Gene Name

Lrrc4

Molecular Weight

100 kDa

Antigen

Fusion protein amino acids 550-652 of mouse NGL-2 (accession number AAG60620); Human: 98% identity (101/103 amino acids identical); Rat: 99% identity (102/103 amino acids identical)

Species Reactivity

Mouse, Rat

Antibody Registry ID

AB_2137614

Storage

Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Buffer

10mM Tris, 50mM Sodium Chloride, 0.065 % Sodium Azide pH 7.4

Conjugate

Unconjugated

Specificity

No cross-reactivity against NGL-1 or NGL-3

Quality Control

Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from opening

Synonyms

Leucine-rich repeat-containing protein 4 (Brain tumor-associated protein MBAG1) (Netrin-G2 ligand) (NGL-2)

UniProt Details

UniProt (Human): Q9HBW1
UniProt (Immunogen Species): Q99PH1

Soto F, Watkins KL, Johnson RE, Schottler F, Kerschensteiner D. (2013), 'NGL-2 regulates pathway-specific neurite growth and lamination, synapse formation, and signal transmission in the retina..' Journal of Neuroscience. 10.1523/JNEUROSCI.1521-13.2013.
DeNardo LA, de Wit J, Otto-Hitt S, Ghosh A. (2012), 'NGL-2 regulates input-specific synapse development in CA1 pyramidal neurons..' Neuron. 10.1016/j.neuron.2012.10.013.
Zhang W, Rajan I, Savelieva KV, Wang CY, Vogel P, Kelly M, Xu N, Hasson B, Jarman W, Lanthorn TH. (2008), 'Netrin-G2 and netrin-G2 ligand are both required for normal auditory responsiveness..' Genes, Brain and Behavior. 10.1111/j.1601-183X.2007.00361.x.

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Anti-NGL-2/LRRC4 Antibody (N50/36)

Anti-NGL-2/LRRC4 Antibody
SKU: 75-084

Bulk Order Anti-NGL-2/LRRC4 Antibody

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Anti-NGL-2/LRRC4 Antibody (N50/36)

Anti-NGL-2/LRRC4 Antibody SKU: 75-084

Bulk Order Anti-NGL-2/LRRC4 Antibody

Product Details

Anti-NGL-2/LRRC4 Antibody
SKU: 75-084