Anti-Navbeta4 Na+ Channel Antibody (N168/6)

Name: Anti-Navbeta4 Na+ Channel Antibody
Brand: NeuroMab
SKU: 75-198
Price: 319.0 USD
Availability: InStock

3 Citations

Our Anti-Navbeta4 Na+ channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N168/6. It detects mouse and rat Navbeta4 Na+ channel, and is purified by Protein A chromatography. It is great for use in IHC, ICC, WB.

Adult rat sciatic nerve immuno-fluorescence staining: paranodes labeled with Caspr (green) surround nodes of Ranvier labeled with Beta-IV spectrin (blue) and N168/6 (red). Images courtesy of Shelly Buffington and Matt Rasband (Baylor College of Medicine).

Adult rat brain immunohistochemistry N168/6 staining in striatal efferents in globus pallidus.

Immunohistochemistry of Purkinje cell bodies and dendrites in cerebellar cortex.

Adult rat brain membrane (RBM) and transfected cell immunoblot: extracts of RBM and COS cells transiently transfected with GFP-tagged Navbeta4 or untagged Kv2.1 plasmid and probed with N168/6 (left), N86/8 (middle) and K89/34 (right) TC supe.

Adult rat sciatic nerve immuno-fluorescence staining: paranodes labeled with Caspr (green) surround nodes of Ranvier labeled with Beta-IV spectrin (blue) and N168/6 (red). Images courtesy of Shelly Buffington and Matt Rasband (Baylor College of Medicine).

Species Reactivity

Mouse, Rat

Applications

ICC, IHC, WB

Host Species

Mouse

Available Conjugates

490

550

594

650

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Data Sheet

SKU: 75-198

Volume: 100 µL

Variant

Price:

$319.00

Quantity:

Product Details

Target

Navbeta4 Na+ channel

Target Description

Sodium channel subunit beta-4 or Navbeta4 Na+ channel is encoded by SCN4B. Voltage gated sodium channels are made up of an alpha (pore forming) subunit and 1 or 2 beta subunits. Navß4 is a transmembrane protein and acts as a regulatory subunit in excitable membranes and modulates the kinetics of channel. Nabß4 is expressed in many tissues, including the brain (dorsal root ganglia), spinal cord, heart, and skeletal muscle. Defects in this gene are a cause of long QT syndrome type 10 and Familial Atrial Fibrillation.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N168/6

Isotype

IgG1

Applications

ICC, IHC, WB

Host Species

Mouse

Gene Name

Scn4b

Molecular Weight

25 kDa

Antigen

Fusion protein amino acids 184-228 (cytoplasmic C-terminus) of rat Navbeta4 (accession number Q7M730) produced recombinantly in E. Coli

Species Reactivity

Mouse, Rat

Antibody Registry ID

AB_2301402

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125

Conjugate

Unconjugated

Specificity

No cross-reactivity reported

Quality Control

Each new lot of antibody is quality control tested on cells overexpressing target protein and confirmed to give the expected staining pattern.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Sodium channel subunit beta-4

UniProt Details

UniProt (Human): Q8IWT1
UniProt (Immunogen Species): Q7M730

Browne L, Smith KE, Jagger DJ. (2017), 'Identification of Persistent and Resurgent Sodium Currents in Spiral Ganglion Neurons Cultured from the Mouse Cochlea..' eNeuro. 10.1523/ENEURO.0303-17.2017.
Ji X, Saha S, Gao G, Lasek AW, Homanics GE, Guildford M, Tapper AR, Martin GE. (2017), 'The Sodium Channel β4 Auxiliary Subunit Selectively Controls Long-Term Depression in Core Nucleus Accumbens Medium Spiny Neurons..' Frontiers in Neuroscience. 10.3389/fncel.2017.00017.
Buffington SA, Rasband MN. (2013), 'Na+ channel-dependent recruitment of Navβ4 to axon initial segments and nodes of Ranvier..' Journal of Neuroscience. 10.1523/JNEUROSCI.4051-12.2013.

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Anti-Navbeta4 Na+ Channel Antibody (N168/6)

SKU: 75-198

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