Adult rat sciatic nerve immuno-fluorescence staining: paranodes labeled with Caspr (green) surround nodes of Ranvier labeled with Beta-IV spectrin (blue) and N168/6 (red). Images courtesy of Shelly Buffington and Matt Rasband (Baylor College of Medicine).
Anti-Navbeta4 Na+ Channel Antibody
Navbeta4 Na+ channel
Sodium channel subunit beta-4 or Navbeta4 Na+ channel is encoded by SCN4B. Voltage gated sodium channels are made up of an alpha (pore forming) subunit and 1 or 2 beta subunits. Navß4 is a transmembrane protein and acts as a regulatory subunit in excitable membranes and modulates the kinetics of channel. Nabß4 is expressed in many tissues, including the brain (dorsal root ganglia), spinal cord, heart, and skeletal muscle. Defects in this gene are a cause of long QT syndrome type 10 and Familial Atrial Fibrillation.
ICC, IHC, WB
Fusion protein amino acids 184-228 (cytoplasmic C-terminus) of rat Navbeta4 (also known as Sodium channel subunit beta-4, Scn4b and Gm1471, accession number Q7M730); Mouse: 100% identity (45/45 amino acids identical); Human: 95% identity (43/45 amino acids identical)
Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
No cross-reactivity reported
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.