Mitogen-activated protein kinase kinase kinase 12, or MAP3K12 is a member of the serine/threonine protein kinase family. MAP3K12 is expressed many tissues including kidney, lung, heart, testis, gastrointestinal tract, stomach, liver and pancreas. In brain, MAP3K12 is mainly expressed in neurons at synaptic terminals. MAP3K12 is thought to initiate signalling cascades which effect the developing mammalian nervous system, including processes such as neuronal migration and axon growth.
ICC, IHC, WB
Fusion protein amino acids 727-888 (C-terminus) of mouse MAP3K12 (also known as Mitogen activated protein kinase kinase kinase 12, Dual leucine zipper bearing kinase, Leucine-zipper protein kinase, MAPK-upstream kinase, Mixed lineage kinase, DLK, ZPK and MUK, accession number Q60700); Rat: 97% identity (158/162 amino acids identical); Human: 86% identity (143/166 amino acids identical); Less than 40% identity with MAP3K13
Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Does not cross-react with MAP3K13
Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.