Anti-Kvbeta2 K+ Channel Antibody (K17/70)

Name: Anti-Kvbeta2 K+ Channel Antibody
Brand: NeuroMab
SKU: 75-021
Price: 295.0 USD
Availability: InStock

from NeuroMab Datasheet KO Validated

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Clonality

Monoclonal

Applications

IHC, IP, WB

Host Species

Mouse

Gene Name

Kcnab2 Ckbeta2 I2rf5 Kcnb3

Molecular Weight

38 kDa (major band)41 kDa (minor band)

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Immunoblot on adult mouse brain membranes from two wild-type (WT1,2) and Kvβ2 knockout (Kvβ2 KO) mice. Brain samples courtesy of Dr. Geoff Murphy, Molecular and Behavioral Neuroscience Institute, University of Michigan.

Adult rat hippocampus immunohistochemistry.

Adult rat brain membrane immunoblot.

Product Details

Target

Kvbeta2 K+ channel

Target Description

Voltage-gated potassium channel subunit beta-2 or Kvß2 is encoded by the gene KCNAB2. Kvß2 is a member of the potassium channel, voltage-gated, shaker-related subfamily. Kvß2 is a cytoplasmic subunit that modulates the characteristics of the membrane spanning, channel-forming alpha-subunits. Beta subunits can promote the closure of channels or enhance channel activity depending on other channel proteins. Kvß2 is expressed in brain, in thecerebellum and in the juxtaparanodal region of nodes of Ranvier. Kvß2 expression is also detected in lung, heart and kidney. Diseases associated with KCNAB2 include Chromosome 1P36 Deletion Syndrome and Juvenile Amyotrophic Lateral Sclerosis 16,

Format

Purified

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

K17/70

Isotype

IgG1

Applications

IHC, IP, WB

Host Species

Mouse

Gene Name

Kcnab2 Ckbeta2 I2rf5 Kcnb3

Molecular Weight

38 kDa (major band)41 kDa (minor band)

Antigen

Fusion protein amino acids 1-367 (full length) of rat Kv2 (accession number NP_034728)Epitope mapped to within amino acids 17-22; Human: 98% identity (362/367); Mouse: 100% identity

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2131373

Storage

Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Buffer

10mM Tris, 50mM Sodium Chloride, 0.065 % Sodium Azide pH 7.4

Conjugate

Unconjugated

Specificity

No cross-reactivity reported

Quality Control

Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from opening

Synonyms

Voltage-gated potassium channel subunit beta-2 (EC 1.1.1.-) (K(+) channel subunit beta-2) (Kv-beta-2) (Neuroimmune protein F5)

UniProt Details

UniProt (Human): Q13303
UniProt (Immunogen Species): P62482

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Anti-Kvbeta2 K+ Channel Antibody (K17/70)

Anti-Kvbeta2 K+ Channel Antibody
SKU: 75-021

Product Details

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Anti-Kvbeta2 K+ Channel Antibody (K17/70)

Anti-Kvbeta2 K+ Channel Antibody SKU: 75-021

Product Details

Anti-Kvbeta2 K+ Channel Antibody
SKU: 75-021