Voltage-gated potassium channel subunit beta-2 or Kvß2 is encoded by the gene KCNAB2. Kvß2 is a member of the potassium channel, voltage-gated, shaker-related subfamily. Kvß2 is a cytoplasmic subunit that modulates the characteristics of the membrane spanning, channel-forming alpha-subunits. Beta subunits can promote the closure of channels or enhance channel activity depending on other channel proteins. Kvß2 is expressed in brain, in thecerebellum and in the juxtaparanodal region of nodes of Ranvier. Kvß2 expression is also detected in lung, heart and kidney. Diseases associated with KCNAB2 include Chromosome 1P36 Deletion Syndrome and Juvenile Amyotrophic Lateral Sclerosis 16,
IHC, IP, WB
Kcnab2 Ckbeta2 I2rf5 Kcnb3
38 kDa (major band)41 kDa (minor band)
Fusion protein amino acids 1-367 (full length) of rat Kv2 (accession number NP_034728)Epitope mapped to within amino acids 17-22; Human: 98% identity (362/367); Mouse: 100% identity
Human, Mouse, Rat
Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
No cross-reactivity reported
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.