Surface immunofluorescence (no detergent permeabilization) of cultured rat hippocampal neuron transfected with HA-tagged Kv2.1 plasmid. Red = K39/25. Scale bar = 20 m. Reproduced from 2000 Lim et al Neuron (PMID 10719893).
Anti-Kv2.1 K+ Channel (External) Antibody
Kv2.1 K+ channel (external)
Potassium voltage-gated channel subfamily B member 1 is encoded by the gene KCNB1. KCNB1 is a member of the potassium channel family, B (Shab) (TC 1.A.1.2) subfamily, Kv2.1/KCNB1 sub-subfamily. KCNB1 is a delayed rectifier potassium channel that mediates transmembrane potassium transport. KCNB1 contributes to the regulation of action potential (AP) repolarization, duration and frequency of repetitive AP firing in neurons, muscle cells, and endocrine cells, and plays a role in homeostatic attenuation of electrical excitability throughout the brain. KCNB1 is expressed in the brain, heart, lung, liver, colon, kidney, and adrenal gland. Diseases associated with KCNB1 include early infantile epileptic encephalopathy 26, undetermined early-onset epileptic encephalopathy, visual epilepsy, and alacrima, achalasia, and mental retardation syndrome.
105-125 kDa (varies with cell background due to phosphorylation)
Synthetic peptide amino acids 211-229 (LPELQSLDEFGQSTDNPQL, extracellular S1-S2 loop) of rat Kv2.1 (also known as potassium voltage-gated channel subfamily B member 1, voltage-gated potassium channel subunit Kv2.1, DRK1, accession number NP_037318); Mouse: 100% identity (19/19 amino acids identical); Human: 100% identity (19/19 amino acids identical)
Human, Mouse, Rat
Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
No cross-reactivity reported
Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
24 months from opening
Potassium voltage-gated channel subfamily B member 1 (Delayed rectifier potassium channel 1) (DRK1) (h-DRK1) (Voltage-gated potassium channel subunit Kv2.1)