Anti-Kv1.1 K+ Channel Antibody (K20/78)


Primary Antibody
Finch, Human, Mouse, Rabbit, Rat
K20/78
ICC, IHC, IP, WB
Mouse
Purified
Kcna1
85 kDa (major: mature glycosylation),65 kDa (minor: immature glycosylation)

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Anti-Kv1.1 K+ Channel Antibody
SKU: 75-007

Volume: 100 µL
Price:
Sale price$345


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Product Specific References for Applications and Species

Affinity Purification: Mouse
PMID Dilution Publication
22067099not listedBildl, W., et al. 2012. Extending the dynamic range of label-free mass spectrometric quantification of affinity purifications.. Molecular & Cellular Proteomics, .
Immunocytochemistry: Human
PMID Dilution Publication
315869451:50Verdura, E., et al. 2020. Complete loss of KCNA1 activity causes neonatal epileptic encephalopathy and dyskinesia. . Journal of Medical Genetics, 132-137.
23774215not listedLallet-Daher, H., et al. 2013. Potassium channel KCNA1 modulates oncogene-induced senescence and transformation.. Cancer Research, 5253-5265.
205806151:50Lai, M., et al. 2010. Investigation of LGI1 as the antigen in limbic encephalitis previously attributed to potassium channels: a case series.. The Lancet Neurology, 776-785.
Immunocytochemistry: Mouse
PMID Dilution Publication
336896791:10Chang, K.J., et al. 2021. TDP-43 maximizes nerve conduction velocity by repressing a cryptic exon for paranodal junction assembly in Schwann cells. . Elife, e64456.
33168717not listedCho, I.H., et al. 2020. The potassium channel subunit Kvβ1 serves as a major control point for synaptic facilitation. . Proceedings of the National Academy of Sciences, 29937-29947.
2436729315 μg/ml Kirchheim, F., et al. 2013. Regulation of action potential delays via voltage-gated potassium Kv1.1 channels in dentate granule cells during hippocampal epilepsy.. Frontiers in Neuroscience, 248.
226417861:1000Glasscock, E., et al. 2012. Transcompartmental reversal of single fibre hyperexcitability in juxtaparanodal Kv1.1-deficient vagus nerve axons by activation of nodal KCNQ channels.. The Journal of Physiology, 3913-3926.
21632923not listedButtermore, E.D., et al. 2011. The cytoskeletal adaptor protein band 4.1B is required for the maintenance of paranodal axoglial septate junctions in myelinated axons.. Journal of Neuroscience, 8013-24.
212332141:1000Fulton, S., et al. 2011. Contribution of Kv1.2 voltage-gated potassium channel to D2 autoreceptor regulation of axonal dopamine overflow.. The Journal of Biological Chemistry, 9360-9372.
Immunocytochemistry: Rabbit
PMID Dilution Publication
20720182not listedLarge, R.J., et al. 2010. Ionic currents in intimal cultured synoviocytes from the rabbit.. American Journal of Physiology-Cell Physiology, C1180-C1194.
Immunocytochemistry: Rat
PMID Dilution Publication
311648061:100Bonetto, G., et al. 2019. Selective axonal expression of the Kv1 channel complex in pre-myelinated GABAergic hippocampal neurons. . Frontiers in Cellular Neuroscience, 222.
23836929not listedSosanya, N.M., et al. 2013. Degradation of high affinity HuD targets releases Kv1.1 mRNA from miR-129 repression by mTORC1.. The Journal of Biology, 53-69.
21357749not listedVacher, H., et al. 2011. Cdk-mediated phosphorylation of the Kvβ2 auxiliary subunit regulates Kv1 channel axonal targeting.. The Journal of Biology, 813-24.
Immunohistochemistry: Human
PMID Dilution Publication
295645315-20ug/mlWillis, M., et al. 2018. Shaker-related voltage-gated potassium channels Kv1 in human hippocampus. . Brain Structure and Function, 2663-2671.
Immunohistochemistry: Mouse
PMID Dilution Publication
346765251:1000Miwa, H., et al. 2021. GAD67-mediated GABA Synthesis and Signaling Impinges on Directing Basket Cell Axonal Projections Toward Purkinje Cells in the Cerebellum.. The Cerebellum, 1-15.
33168717not listedCho, I.H., et al. 2020. The potassium channel subunit Kvβ1 serves as a major control point for synaptic facilitation. . Proceedings of the National Academy of Sciences, 29937-29947.
287126541:500Favuzzi, E., et al. 2017. Activity-dependent gating of parvalbumin interneuron function by the perineuronal net protein brevican. . Neuron, 639-655.
26269632not listedSmith, K.E., et al. 2015. Phosphoinositide Modulation of Heteromeric Kv1 Channels Adjusts Output of Spiral Ganglion Neurons from Hearing Mice.. Journal of Neuroscience, 11221-11232.
246878761:250King, C.H., et al. 2014. Kv7.2 regulates the function of peripheral sensory neurons.. Journal of Comparative Neurology, 3262-3280.
230909901:1000Nguyen, H.M., et al. 2012. Modulation of voltage-gated K+ channels by the sodium channel β1 subunit.. Proceedings of the National Academy of Science of the United States of America, 18577-18582.
21958379not listedDuflocq, A., et al. 2011. Characterization of the axon initial segment (AIS) of motor neurons and identification of a para-AIS and a juxtapara-AIS, organized by protein 4.1B.. BMC Biology, 1-19.
216764991:100Wykes, R., et al. 2012. Changes in the physiology of CA1 hippocampal pyramidal neurons in preplaque CRND8 mice. . Neurobiology of aging, 1609-1623.
216329491:500Hirtz, J.J., et al. 2011. Cav1.3 calcium channels are required for normal development of the auditory brainstem.. Journal of Neuroscience, 8280-94.
205750681:100Gazula, V.R., et al. 2010. Localization of Kv1.3 channels in presynaptic terminals of brainstem auditory neurons.. Journal of Comparative Neurology, 3205-20.
212332141:1000Fulton, S., et al. 2011. Contribution of Kv1.2 voltage-gated potassium channel to D2 autoreceptor regulation of axonal dopamine overflow.. The Journal of Biological Chemistry, 9360-9372.
Immunohistochemistry: Rat
PMID Dilution Publication
347994471:100Zbili, M., et al. 2021. Homeostatic regulation of axonal Kv1. 1 channels accounts for both synaptic and intrinsic modifications in the hippocampal CA3 circuit. . Proceedings of the National Academy of Sciences, e2110601118.
323456731:300Housley, S.N., et al. 2020. Cancer Exacerbates Chemotherapy-Induced Sensory NeuropathyCancer Exacerbates Chemotherapy-Induced Sensory Neuropathy. . Cancer research, 2940-2955.
247232631:100Dufour, M.A., et al. 2014. Somatodendritic ion channel expression in substantia nigra pars compacta dopaminergic neurons across postnatal development.. Journal of Neuroscience Research, 981-99.
245235571:100Tagoe, T., et al. 2014. Auditory nerve perinodal dysmyelination in noise-induced hearing loss. Journal of Neuroscience, 2684-2688.
23318870not listedOvsepian, S.V., et al. 2013. A defined heteromeric KV1 channel stabilizes the intrinsic pacemaking and regulates the output of deep cerebellar nuclear neurons to thalamic targets.. The Journal of Physiology, 1771-91.
22473424not listedHuang, C.Y., et al. 2012. Coexpression of high-voltage-activated ion channels Kv3.4 and Cav1.2 in pioneer axons during pathfinding in the developing rat forebrain.. Journal of Comparative Neurology, 3650-3672.
217343021:200Lysakowski, A., et al. 2011. Molecular microdomains in a sensory terminal, the vestibular calyx ending.. Journal of Neuroscience, 10101-10114.
Immunohistochemistry: Zebra Finch
PMID Dilution Publication
319375581:500Chen, A.N., et al. 2020. Experience-and sex-dependent intrinsic plasticity in the zebra finch auditory cortex during song memorization. . Journal of Neuroscience, 2047-2055.
Immunoprecipitation: Mouse
PMID Dilution Publication
28712654not listedFavuzzi, E., et al. 2017. Activity-dependent gating of parvalbumin interneuron function by the perineuronal net protein brevican. . Neuron, 639-655.
Western Blot: Human
PMID Dilution Publication
29564531not listedWillis, M., et al. 2018. Shaker-related voltage-gated potassium channels Kv1 in human hippocampus. . Brain Structure and Function, 2663-2671.
278720491:2000Nishijima, Y., et al. 2017. Contribution of Kv1. 5 channel to hydrogen peroxide–induced human arteriolar dilation and its modulation by coronary artery disease. . Circulation research, 658-669.
Western Blot: Mouse
PMID Dilution Publication
321301081:1000Siems, S.B., et al. 2020. Proteome profile of peripheral myelin in healthy mice and in a neuropathy model.. Elife, e51406.
33157003not listedKuijpers, M., et al. 2021. Neuronal Autophagy Regulates Presynaptic Neurotransmission by Controlling the Axonal Endoplasmic Reticulum. Neuron, 299-313.
32437528not listedRamberger, M., et al. 2020. Distinctive binding properties of human monoclonal LGI1 autoantibodies determine pathogenic mechanisms. Brain, 1731-1745.
30586380not listedFavaro, P.D., et al. 2018. An opposing function of paralogs in balancing developmental synapse maturation. Plos Biology, e2006838.
29564531not listedWillis, M., et al. 2018. Shaker-related voltage-gated potassium channels Kv1 in human hippocampus. . Brain Structure and Function, 2663-2671.
294761051:1000Nguyen, L.H., et al. 2018. mTOR-dependent alterations of Kv1.1 subunit expression in the neuronal subset-specific Pten knockout mouse model of cortical dysplasia with epilepsy. Scientific Reports, 3568.
287126541:500Favuzzi, E., et al. 2017. Activity-dependent gating of parvalbumin interneuron function by the perineuronal net protein brevican. . Neuron, 639-655.
262696481:400Kole, M.J., et al. 2015. Selective loss of presynaptic potassium channel clusters at the cerebellar basket cell terminal pinceau in adam11 mutants reveals their role in ephaptic control of purkinje cell firing. . Journal of Neuroscience, 11433-11444.
22385959not listedHuang, Y.W., et al. 2012. Dual regulation of miRNA biogenesis generates target specificity in neurotrophin-induced protein synthesis.. Cell, 933-46.
221314241:500Kaphzan, H., et al. 2011. Alterations in intrinsic membrane properties and the axon initial segment in a mouse model of Angelman syndrome.. Journal of Neuroscience, 17637-48.
219436061:1000Sun, W., et al. 2011. DPP6 establishes the A-type K(+) current gradient critical for the regulation of dendritic excitability in CA1 hippocampal neurons.. Neuron, 1102-15.
20575068not listedGazula, V.R., et al. 2010. Localization of Kv1.3 channels in presynaptic terminals of brainstem auditory neurons.. Journal of Comparative Neurology, 3205-20.
Western Blot: Rat
PMID Dilution Publication
237929471:200Zhao, X., et al. 2013. A long noncoding RNA contributes to neuropathic pain by silencing Kcna2 in primary afferent neurons.. Nature Neuroscience, 1024-1031.
235367711:1000Brewster, A.L., et al. 2013. Rapamycin reverses status epilepticus-induced memory deficits and dendritic damage.. PLoS One, e57808.
233188701:10Ovsepian, S.V., et al. 2013. A defined heteromeric KV1 channel stabilizes the intrinsic pacemaking and regulates the output of deep cerebellar nuclear neurons to thalamic targets.. The Journal of Physiology, 1771-91.
230660171:2000Yao, J.J., et al. 2012. Neuritin activates insulin receptor pathway to up-regulate Kv4.2-mediated transient outward K+ current in rat cerebellar granule neurons.. The Journal of Biological Chemistry, 41534-41545.
Additional Publications: Unspecified
PMID Publication
25707359Chen, N., et al. 2015. Interaction proteomics of canonical Caspr2 (CNTNAP2) reveals the presence of two Caspr2 isoforms with overlapping interactomes. . Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics, 827-833.
22492029Buttermore, E.D., et al. 2012. Pinceau organization in the cerebellum requires distinct functions of neurofascin in Purkinje and basket neurons during postnatal development.. Journal of Neuroscience, 4724-4742.
22291039Ivanovic, A., et al. 2012. The cytoskeletal adapter protein 4.1G organizes the internodes in peripheral myelinated nerves.. The Journal of Biology, 337-44.
21906755Loukaides, P., et al. 2012. Morvan''s syndrome associated with antibodies to multiple components of the voltage-gated potassium channel complex. Journal of the Neurological Sciences, 52-56.
21220016Giacomini, C., et al. 2011. Both Schwann cell and axonal defects cause motor peripheral neuropathy in Ebf2-/- mice.. Neurobiology of Disease, 73-84.
20392939Glasscock, E., et al. 2010. Kv1.1 potassium channel deficiency reveals brain-driven cardiac dysfunction as a candidate mechanism for sudden unexplained death in epilepsy.. Journal of Neuroscience, 5167-5175.
20133599Fukata, Y., et al. 2010. Disruption of LGI1–linked synaptic complex causes abnormal synaptic transmission and epilepsy. . Proceedings of the National Academy of Sciences, 3799-3804.
20089912Ogawa, Y., et al. 2010. ADAM22, a Kv1 channel-interacting protein, recruits membrane-associated guanylate kinases to juxtaparanodes of myelinated axons. . Journal of Neuroscience, 1038-1048.
19903818van der Wijst, J., et al. 2010. Functional analysis of the Kv1.1 N255D mutation associated with autosomal dominant hypomagnesemia.. The Journal of Biological Chemistry, 171-178.
19818338Toyoshima, M., et al. 2009. Deficiency of neural recognition molecule NB-2 affects the development of glutamatergic auditory pathways from the ventral cochlear nucleus to the superior olivary complex in mouse.. Developmental Biology, 192-200.
19307729Glaudemans, B., et al. 2009. A missense mutation in the Kv1.1 voltage-gated potassium channel-encoding gene KCNA1 is linked to human autosomal dominant hypomagnesemia.. Journal of Clinical Investigation, 936-942.
19091962Miller, M.N., et al. 2008. Region-specific spike-frequency acceleration in layer 5 pyramidal neurons mediated by Kv1 subunits.. Journal of Neuroscience, 13716-13726.
17651419Wenzel, H.J., et al. 2007. Structural consequences of Kcna1 gene deletion and transfer in the mouse hippocampus.. Epilepsia, 2023-2046.
17185748Vacher, H., et al. 2007. Regulation of Kv1 channel trafficking by the mamba snake neurotoxin dendrotoxin K.. The FASEB Journal, 906-914.
17145502Gu, C., et al. 2006. The microtubule plus-end tracking protein EB1 is required for Kv1 voltage-gated K+ channel axonal targeting.. Neuron, 803-816.
18684900Pineda, R.H, et al. 2008. Kv1 potassium channel complexes in vivo require Kvβ2 subunits in dorsal spinal neurons. . Journal of neurophysiology, 2125-2136.
22886464Engelhardt, M., et al. 2013. Ankyrin-B structurally defines terminal microdomains of peripheral somatosensory axons.. Brian Structure and Function, 1005-1016.

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