Array tomography immunofluorescence of an LRWhite-embedded 70 nm section from adult mouse cortex layer 5 with L117/1 (red), rabbit mAb PSD-95 (Cell Signaling #3450, green) and DAPI (blue), where L117/1 colocalizes with some PSD-95 puncta. Image courtesy of Kristina Micheva (Stanford)..
Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI-associated protein 2) (BAI1-associated protein 2) (Protein BAP2) (Fas ligand-associated factor 3) (FLAF3) (Insulin receptor substrate p53/p58) (IRS-58) (IRSp53/58) (Insulin receptor substrate protein of 53 kDa) (IRSp53) (Insulin receptor substrate p53)
Brain-specific angiogenesis inhibitor 1-associated protein 2 or IRSp53/BAIAP2 is encoded by the gene BAIAP2 and is a MAGUK (membrane-associted guanylase kinase homolog) family. BAIAP2 is an adaptor protein which links G-proteins in the membrane to cytoplasmic proteins and is involved in cell processes including regulation of the actin cytoskeleton, neurite growth and the promotion of filipodia formation. Multiple isoforms of BAIAP2 exist with differential tissue expression. Diseases associated with BAIAP2 include Dentatorubral-Pallidoluysian Atrophy and Attention Deficit-Hyperactivity Disorder.
AT, ICC, IHC, WB
Fusion protein amino acids 1-250 (N-terminus) of human BAIAP2 (also known as Brain-specific angiogenesis inhibitor 1-associated protein 2, BAI-associated protein 2, BAI1-associated protein 2, Insulin receptor substrate p53/p58, Insulin receptor substrate protein of 53 kDa, Insulin receptor tyrosine kinase 53 kDa substrate, Insulin receptor tyrosine kinase substrate protein p53, Fas ligand-associated factor 3, BAP2, IRS-58, IRSp53/58, IRSp53 and FLAF3, accession number Q9UQB8); Mouse: 97% identity (243/250 amino acids identical); Rat: 97% identity (242/250 amino acids identical); 50% identity with BAIAP2L1
Human, Mouse, Rat
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