Anti-IRSp53/BAIAP2 Antibody (L117/1)

Name: Anti-IRSp53/BAIAP2 Antibody
Brand: NeuroMab
SKU: 75-449
Price: 329.0 USD
Availability: InStock

2 Citations

Our Anti-IRSp53/BAIAP2 mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone L117/1. It detects human, mouse, and rat IRSp53/BAIAP2, and is purified by Protein A chromatography. It is great for use in AT, IHC, ICC, WB.

Array tomography immunofluorescence of an LRWhite-embedded 70 nm section from adult mouse cortex layer 5 with L117/1 (red), rabbit mAb PSD-95 (Cell Signaling

Adult rat hippocampus immunohistochemistry.

Array tomography immunofluorescence of an LRWhite-embedded 70 nm section from adult mouse cortex layer 5 with L117/1 (red), rabbit mAb PSD-95 (Cell Signaling #3450, green) and DAPI (blue), where L117/1 colocalizes with some PSD-95 puncta. Image courtesy of Kristina Micheva (Stanford)..

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Species Reactivity

Human, Mouse, Rat

Applications

ICC, IHC, WB

Host Species

Mouse

Conjugates and Formulations

490

550

594

650

Carrier-Free

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Data Sheet

SKU: 75-449

Volume: 100 µL

Variant

Price:

$329.00

Quantity:

Ships: 1-2 business days

Product Details

Target

IRSp53/BAIAP2

Scientific Background

Brain-specific angiogenesis inhibitor 1-associated protein 2 or IRSp53/BAIAP2 is encoded by the gene BAIAP2 and is a MAGUK (membrane-associted guanylase kinase homolog) family. BAIAP2 is an adaptor protein which links G-proteins in the membrane to cytoplasmic proteins and is involved in cell processes including regulation of the actin cytoskeleton, neurite growth and the promotion of filipodia formation. Multiple isoforms of BAIAP2 exist with differential tissue expression. Diseases associated with BAIAP2 include Dentatorubral-Pallidoluysian Atrophy and Attention Deficit-Hyperactivity Disorder.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

L117/1

Isotype

IgG1

Applications

ICC, IHC, WB

Host Species

Mouse

Gene Name

BAIAP2

Molecular Weight

50-60 kDa

Immunogen

Fusion protein amino acids 1-250 (N-terminus) of human BAIAP2 (accession number Q9UQB8) produced recombinantly in E. Coli

Immunogen Species

Human

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2651164

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125

Dilution Ranges

IHC: 1:100

Conjugate

Unconjugated

Specificity

No cross-reactivity reported

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Synonyms

Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAI-associated protein 2) (BAI1-associated protein 2) (Protein BAP2) (Fas ligand-associated factor 3) (FLAF3) (Insulin receptor substrate p53/p58) (IRS-58) (IRSp53/58) (Insulin receptor substrate protein of 53 kDa) (IRSp53) (Insulin receptor substrate p53)

UniProt ID

Q9UQB8

Shipping

Shipped on ice packs

Product Specific References for Applications and Species

Western Blot: Rat

Western Blot: Rat
PMID	Dilution	Publication
31439005	1:100	Dosemeci, A., et al. 2019. Postsynaptic densities fragment into subcomplexes upon sonication. Molecular Brain, 72.
29284046	1:4 (supe)	Dosemeci, A., et al. 2017. IRSp53 accumulates at the postsynaptic density under excitatory conditions. PLoS One, e0190250.

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Anti-IRSp53/BAIAP2 Antibody (L117/1)

SKU: 75-449

Product Details

Product Specific References for Applications and Species

Bulk Order Anti-IRSp53/BAIAP2 Antibody

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