Anti-GluR2 Antibody

Name: Anti-GluR2 Antibody
Brand: PhosphoSolutions
SKU: 900-GluR2
Price: 430.0 USD
Availability: InStock

4 Citations

Our Anti-GluR2 rabbit polyclonal primary antibody from PhosphoSolutions is produced in-house. It detects rat GluR2 and is antigen affinity purified from pooled serum. It is great for use in WB.

Western blot of a rat hippocampal lysate showing the specific immunolabeling of the ~100 kDa GluR2 protein.

Species Reactivity

Rat

Applications

Host Species

Rabbit

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Data Sheet

Trial Size

Pooled Serum

SKU: 900-GluR2

Volume: 100 µL

Variant

Price:

$430.00

Quantity:

Product Details

Target

GluR2

Target Description

The ion channels activated by glutamate are typically divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR) while those activated by α-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as AMPA receptors (AMPAR). The AMPAR are comprised of four distinct glutamate receptor subunits designated (GluR1-4) and they play key roles in virtually all excitatory neurotransmission in the brain (Keinänen et al., 1990;Hollmann and Heinemann, 1994). The GluR2 subunit is thought to play a key role in forms of synaptic plasticity such as LTD (Chung et al., 2003).

Format

Antigen Affinity Purified from Pooled Serum

Clonality

Polyclonal

Isotype

IgG

Applications

Host Species

Rabbit

Gene Name

GRIA2

Molecular Weight

100 kDa

Antigen

Synthetic peptide corresponding to amino acid residues specific to GluR2, conjugated to keyhole limpet hemocyanin (KLH).

Species Reactivity

Rat

Expected Reactivity

Chicken, Human, Non-Human Primate, Mouse, Zebrafish

Antibody Registry ID

AB_2492129

Storage

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Physical State

Liquid

Production Notes

Prepared from rabbit serum by affinity purification using a column to which the peptide immunogen was coupled.

Buffer

10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.

Dilution Ranges

WB: 1:1000
WB Brain: 1:1000

Conjugate

Unconjugated

Specificity

Specific for endogenous levels of the ~100 kDa GluR2 protein.

Quality Control

Western blots performed on each lot.

Usage Statement

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Expiration

After date of receipt, stable for at least 1 year at -20°C.

Shipping

Blue Ice

Synonyms

AMPA 2 antibody, AMPA selective glutamate receptor 2 antibody, AMPA-selective glutamate receptor 2 antibody, AMPA2 antibody, GluA2 antibody, GLUR 2 antibody, GLUR B antibody, GluR K2 antibody, GluR-2 antibody, GluR-B antibody, GluR-K2 antibody, GLUR2 antibody, GLURB antibody, Glutamate receptor 2 antibody, Glutamate receptor ionotropic AMPA 2 antibody, Glutamate receptor ionotropic antibody, Gria2 antibody, GRIA2_HUMAN antibody, HBGR2 antibody

UniProt Details

UniProt (Human): P42262
UniProt (Immunogen Species): P19491

NCBI Gene ID

29627

Product Specific References for Applications and Species

Western Blot: Rat

Western Blot: Rat
PMID	Dilution	Publication
29432883	not listed	Mao, M., et al. 2018. Regulation of Phosphorylation of AMPA Glutamate Receptors by Muscarinic M4 Receptors in the Striatum In vivo. Neuroscience, 375, pp.84-93.
28578480	not listed	Lameth, J., et al. 2017. Acute Neuroinflammation Promotes Cell Responses to 1800 MHz GSM Electromagnetic Fields in the Rat Cerebral Cortex. Neurotoxicity Research, pp.1-16.
25689263	1:1000	Mao, L.M., et al. 2015. Dynamic increases in AMPA receptor phosphorylation in the rat hippocampus in response to amphetamine. Journal of neurochemistry, 133(6), pp.795-805.
24231469	1:1000	Xue, B., et al. 2015. Rapid and sustained GluA1 S845 phosphorylation in synaptic and extrasynaptic locations in the rat forebrain following amphetamine administration. Neurochemistry international, 64, pp.48-54.

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Product Specific Protocols

Western Blot Protocol: Download

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Anti-GluR2 Antibody

SKU: 900-GluR2

Product Details

Product Specific References for Applications and Species

Bulk Order Anti-GluR2 Antibody

Product Specific Protocols

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