Anti-Cav1.3 Ca2+ Channel Antibody (L48A/9)

Name: Anti-Cav1.3 Ca2+ Channel Antibody
Brand: NeuroMab
SKU: 75-113
Price: 329.0 USD
Availability: InStock

9 Citations

Our Anti-Cav1.3 Ca2+ channel mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone L48A/9. It detects human, mouse, and rat Cav1.3 Ca2+ channel, and is purified by Protein A chromatography. It is great for use in IHC, ICC, IP, WB.

Adult rat hippocampus immunohistochemistry.

Adult rat brain membrane immunoblot.

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Species Reactivity

Human, Mouse, Rat

Applications

ICC, IHC, IP, WB

Host Species

Mouse

Conjugates and Formulations

490

550

594

650

Carrier-Free

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Data Sheet

SKU: 75-113

Volume: 100 µL

Variant

Price:

$329.00

Quantity:

Ships: 1-2 business days

Product Details

Target

Cav1.3 Ca2+ channel

Scientific Background

Voltage-dependent L-type calcium channel subunit alpha-1D, or Cav1.3 calcium channel is a calcium channel encoded by the gene CACNA1D. It is a member of the L type voltage dependent calcium channel family. These calcium channels mediate the influx of calcium ions into a cell upon membrane polarization. Cav1.3 is expressed primarily in the membrane of the heart, brain (cerebral cortex, hippocampus, basal ganglia and thalamus). and pancreatic islets. Calcium channels are involved in many cell processes including muscle contraction, neurotransmitter release, gene expression, cell division and cell death. Diseases associated with Cav1.3 include Primary Aldosteronism, Seizures, Sinoatrial Node Dysfunction and Deafness.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

L48A/9

Isotype

IgG2a

Applications

ICC, IHC, IP, WB

Host Species

Mouse

Gene Name

Cacna1d Cach3 Cacn4 Cacnl1a2 Cchl1a2

Molecular Weight

250 kDa

Immunogen

Synthetic peptide amino acids 859-875 (N-terminus) of rat Cav1.3 (accession number P27732)

Immunogen Species

Rat

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2069388

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.41

Conjugate

Unconjugated

Specificity

No cross-reactivity against Cav1.2

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Synonyms

Voltage-dependent L-type calcium channel subunit alpha-1D (Calcium channel, L type, alpha-1 polypeptide, isoform 2) (Rat brain class D) (RBD) (Voltage-gated calcium channel subunit alpha Cav1.3)

UniProt ID

P27732

Shipping

Shipped on ice packs

Product Specific References for Applications and Species

Immunocytochemistry: Human | Mouse
Immunohistochemistry: Mouse | Rabbit | Rat
Western Blot: Mouse | Rat
Additional Publications: Unspecified

Immunocytochemistry: Human
PMID	Dilution	Publication
19860837	not listed	Hettiarachchi, N.T., et al. 2009. alpha-Synuclein modulation of Ca2+ signaling in human neuroblastoma (SH-SY5Y) cells.. Journal of Neurochemistry, 1192-1201.

Immunocytochemistry: Mouse
PMID	Dilution	Publication
25538241	not listed	Lu, L., et al. 2015. Regulation of gene transcription by voltage-gated L-type calcium channel, Cav1.3.. The Journal of Biological Chemistry, 4663-4676.
23761910	1:500	Dryanovski, D.I., et al. 2013. Calcium entry and α-synuclein inclusions elevate dendritic mitochondrial oxidant stress in dopaminergic neurons.. Journal of Neuroscience, 10154-10164.

Immunohistochemistry: Mouse
PMID	Dilution	Publication
22892111	1:500	Zou, J., et al. 2012. The expression of whirlin and Cav1.3α₁ is mutually independent in photoreceptors.. Vision Research, 53-59.

Immunohistochemistry: Rabbit
PMID	Dilution	Publication
25540577	not listed	Frederikse, P., et al. 2014. PTBP-dependent PSD-95 and CamKIIα alternative splicing in the lens. Molecular Vision, 1660-1667.

Immunohistochemistry: Rat
PMID	Dilution	Publication
27383597	not listed	Philippart, F., et al. 2016. Differential Somatic Ca2+ Channel Profile in Midbrain Dopaminergic Neurons. Journal of Neuroscience, 7234-7245.

Western Blot: Mouse
PMID	Dilution	Publication
22892111	1:1000	Zou, J., et al. 2012. The expression of whirlin and Cav1.3α₁ is mutually independent in photoreceptors.. Vision Research, 53-59.
22745805	1:500	Yamasaki, S., et al. 2012. A novel role of the L-type calcium channel α1D subunit as a gatekeeper for intracellular zinc signaling: zinc wave.. PLoS One, e39654.

Western Blot: Rat
PMID	Dilution	Publication
25610372	1:1000	Perissinotti, P.P., et al. 2015. Calcium current homeostasis and synaptic deficits in hippocampal neurons from Kelch-like 1 knockout mice.. Frontiers in Neuroscience, 444.

Additional Publications: Unspecified
PMID	Publication
24703904	Perissinotti, P.P., et al. 2014. Down-regulation of endogenous KLHL1 decreases voltage-gated calcium current density.. Cell Calcium, 269-280.

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Anti-Cav1.3 Ca2+ Channel Antibody (L48A/9)

SKU: 75-113

Product Details

Product Specific References for Applications and Species

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