Anti-Cav1.2 Ca2+ Channel Antibody (L57/46)


Primary Antibody
Human, Mouse, Rat
L57/46
IHC, IP, WB
Mouse
Purified
CACNA1C CACH2 CACN2 CACNL1A1 CCHL1A1
240 kDa(varies with cell background due to glycosylation)

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Anti-Cav1.2 Ca2+ Channel Antibody
SKU: 75-053

Volume: 100 µL
Price:
Sale price$308


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Product Specific References for Applications and Species

Immunocytochemistry: Human
PMID Dilution Publication
261537971:100Assou, S., et al. 2015. Cultured Cells from the Human Oocyte Cumulus Niche Are Efficient Feeders to Propagate Pluripotent Stem Cells.. Stem Cells and Development, 2317-2327.
24365142not listedRobert, V., et al. 2014. Protein kinase C-dependent activation of CaV1.2 channels selectively controls human TH2-lymphocyte functions.. The Journal of Allergy and Clinical Immunology, 1175-1183.
Immunocytochemistry: Mouse
PMID Dilution Publication
29129580not listedRosa, N., et al. 2018. The β and α2δ auxiliary subunits of voltage-gated calcium channel 1 (Cav1) are required for TH2 lymphocyte function and acute allergic airway inflammation. Journal of Allergy and Clinical Immunology, 892-903.
235769581:200Ginger, M., et al. 2013. Three-dimensional tracking and analysis of ion channel signals across dendritic arbors. Frontiers in Neural Circuits, 61.
216744941:100Brandao, K.E., et al. 2012. A-kinase anchoring protein 150 expression in a specific subset of TRPV1- and CaV 1.2-positive nociceptive rat dorsal root ganglion neurons.. Journal of Comparative Neurology, 81-99.
20652277not listedAltomare, C., et al. 2010. Caffeine-induced Ca(2+) signaling as an index of cardiac progenitor cells differentiation.. Basic Research in Cardiology, 737-749.
Immunocytochemistry: Rat
PMID Dilution Publication
344319811:100Isensee, J., et al. 2021. Depolarization induces nociceptor sensitization by CaV1.2-mediated PKA-II activation. Journal of Cellular Biology, .
216744941:100Brandao, K.E., et al. 2012. A-kinase anchoring protein 150 expression in a specific subset of TRPV1- and CaV 1.2-positive nociceptive rat dorsal root ganglion neurons.. Journal of Comparative Neurology, 81-99.
Immunohistochemistry: Human
PMID Dilution Publication
237713391:100Hurley, M.J., et al. 2013. Parkinson''s disease is associated with altered expression of CaV1 channels and calcium-binding proteins.. Brain, 2077-2097.
Immunohistochemistry: Mouse
PMID Dilution Publication
21216955not listedFu, Y., et al. 2011. Deletion of the distal C terminus of CaV1.2 channels leads to loss of beta-adrenergic regulation and heart failure in vivo.. Journal of Biological Chemistry, 12617-12626.
208266781:50Zorrilla de San Martín, J., et al. 2010. Ca(2+) and Ca(2+)-activated K(+) channels that support and modulate transmitter release at the olivocochlear efferent-inner hair cell synapse.. Journal of Neuroscience, 12157-12167.
Immunohistochemistry: Rat
PMID Dilution Publication
237713391:100Hurley, M.J., et al. 2013. Parkinson''s disease is associated with altered expression of CaV1 channels and calcium-binding proteins.. Brain, 2077-2097.
218045291:200Favereaux, A., et al. 2011. Bidirectional integrative regulation of Cav1.2 calcium channel by microRNA miR-103: role in pain. EMBO Journal, 3830-3841.
200899161:200Fossat, P., et al. 2010. Knockdown of L calcium channel subtypes: differential effects in neuropathic pain.. Journal of Neuroscience, 1073-1085.
Immunoprecipitation: Human
PMID Dilution Publication
211863552ugAltier, C., et al. 2011. The Cavβ subunit prevents RFP2-mediated ubiquitination and proteasomal degradation of L-type channels.. Nature Neuroscience, 173-180.
Western Blot: Guinea Pig
PMID Dilution Publication
30075281not listedZankov, D.P., et al. 2019. Chronic in vivo angiotensin II administration differentially modulates the slow delayed rectifier channels in atrial and ventricular myocytes. Heart Rhythm, 108-116.
23019291not listedCutler, M.J., et al. 2013. Targeted sarcoplasmic reticulum Ca2+ ATPase 2a gene delivery to restore electrical stability in the failing heart.. Circulation, 2095-2104.
20371314not listedWang, X., et al. 2010. Phospholemman modulates the gating of cardiac L-type calcium channels.. Biophysical Journal, 1149-1159.
Western Blot: Human
PMID Dilution Publication
341630371:1000Rodan, L.H., et al. 2021. Phenotypic expansion of CACNA1C-associated disorders to include isolated neurological manifestations. Genetic Medicine, 19221932.
280498251:1000Caballero, R., et al. 2017. Tbx20 controls the expression of the KCNH2 gene and of hERG channels. PNAS: USA, E416-E425.
252677191:1000Li, L., et al. 2015. Potentiation of high voltage-activated calcium channels by 4-aminopyridine depends on subunit composition.. Molecular Pharmacology, 760-772.
251074491:1000Barana, A., et al. 2015. Chronic atrial fibrillation increases microRNA-21 in human atrial myocytes decreasing L-type calcium current.. Circulation: Arrhythmia and Electrophysiology, 861-868.
23287412not listedValerie, N.C., et al. 2013. Inhibition of T-type calcium channels disrupts Akt signaling and promotes apoptosis in glioblastoma cells.. Biochem Pharmacol., 888-897.
22891239not listedWilson, S.M., et al. 2013. Inhibition of transmitter release and attenuation of anti-retroviral-associated and tibial nerve injury-related painful peripheral neuropathy by novel synthetic Ca2+ channel peptides.. Journal of Biological Chemistry, 35065-35077.
22627147not listedBrittain, J.M., et al. 2013. Regulation of CREB signaling through L-type Ca2+ channels by Nipsnap-2.. Channels, 94-102.
19860837not listedHettiarachchi, N.T., et al. 2009. alpha-Synuclein modulation of Ca2+ signaling in human neuroblastoma (SH-SY5Y) cells.. Journal of Neurochemistry, 1192-1201.
Western Blot: Mouse
PMID Dilution Publication
361426391:10Thibault, S., et al. 2022. Higher Na+-Ca2+ Exchanger Function and Triggered Activity Contribute to Male Predisposition to Atrial Fibrillation. International Journal of Molecular Science, 10724.
31822608not listedHasan, R., et al. 2019. SUMO1 modification of PKD2 channels regulates arterial contractility. PNAS: USA, 27095-27104.
305116401:100Bulley, S., et al. 2018. Arterial smooth muscle cell PKD2 (TRPP1) channels regulate systemic blood pressure. Elife, e42628.
271220981:200Eden, M., et al. 2016. Myoscape controls cardiac calcium cycling and contractility via regulation of L-type calcium channel surface expression. Nature Communications, 11317.
241672261:1000Tajada, S., et al. 2014. Down-regulation of CaV1.2 channels during hypertension: how fewer CaV1.2 channels allow more Ca(2+) into hypertensive arterial smooth muscle.. The Journal of Physiology, 6175-6191.
24033980not listedNúñez‐Santana, F.L., et al. 2014. Surface L-type Ca2+ channel expression levels are increased in aged hippocampus.. Aging Cell, 111-120.
226101741:500LaRocca, T.J., et al. 2012. Na+/Ca2+ exchanger-1 protects against systolic failure in the Akitains2 model of diabetic cardiomyopathy via a CXCR4/NF-κB pathway.. American Journal of Physiology-Heart and Circulatory Physiology, H353-367.
19461043not listedThomsen, M.B., et al. 2010. Accessory subunit KChIP2 modulates the cardiac L-type calcium current.. Circulation Research, 1382-1289.
181848311:200Télémaque, S., et al. 2008. Design of mutant beta2 subunits as decoy molecules to reduce the expression of functional Ca2+ channels in cardiac cells.. Journal of Pharmacology and Experimental Therapeutics, 37-46.
Western Blot: Rabbit
PMID Dilution Publication
20405051not listedXu, X., et al. 2010. Long-term fish oil supplementation induces cardiac electrical remodeling by changing channel protein expression in the rabbit model.. PLoS One, e10140.
Western Blot: Rat
PMID Dilution Publication
271145591:1000Lu, J.M., et al. 2016. GDF-15 enhances intracellular Ca2+ by increasing Cav1.3 expression in rat cerebellar granule neurons. Biochemical Journal, 1895-1904.
259047921:150Kim, H.H., et al. 2015. Costimulation of AMPA and metabotropic glutamate receptors underlies phospholipase C activation by glutamate in hippocampus.. Journal of Neuroscience, 6401-6412.
23568894not listedBannister, J.P., et al. 2013. The voltage-dependent L-type Ca2+ (CaV1.2) channel C-terminus fragment is a bi-modal vasodilator.. The Journal of Physiology, 2987-2998.
234575531:4 (supe)Bissig, D., Goebel, D. and Berkowitz, B.A., et al. 2013. Diminished vision in healthy aging is associated with increased retinal L-type voltage gated calcium channel ion influx.. PLoS One, e56340.
22847236not listedRamos-Mondragon, R., et al. 2013. Chronic potentiation of cardiac L-type Ca(2+) channels by pirfenidone.. Cardiovascular Research, 244-254.
Additional Publications: Unspecified
PMID Publication
21195084Bobe, R., et al. 2011. SERCA2a controls the mode of agonist-induced intracellular Ca2+ signal, transcription factor NFAT and proliferation in human vascular smooth muscle cells.. Journal of Molecular and Cellular Cardiology, 621-633.

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