Anti-Cav1.2 Ca2+ Channel Antibody (L57/46)
Primary Antibody
Human, Mouse, Rat
L57/46
IHC, IP, WB
Mouse
Purified
CACNA1C CACH2 CACN2 CACNL1A1 CCHL1A1
240 kDa(varies with cell background due to glycosylation)
Adult rat hippocampus immunohistochemistry.
Product Specific References for Applications and Species
- Immunocytochemistry: Human | Mouse | Rat
- Immunohistochemistry: Human | Mouse | Rat
- Immunoprecipitation: Human
- Western Blot: Guinea Pig | Human | Mouse | Rabbit| Rat
- Additional Publications: Unspecified
| Immunocytochemistry: Human | ||
| PMID | Dilution | Publication |
| 26153797 | 1:100 | Assou, S., et al. 2015. Cultured Cells from the Human Oocyte Cumulus Niche Are Efficient Feeders to Propagate Pluripotent Stem Cells.. Stem Cells and Development, 2317-2327. |
| 24365142 | not listed | Robert, V., et al. 2014. Protein kinase C-dependent activation of CaV1.2 channels selectively controls human TH2-lymphocyte functions.. The Journal of Allergy and Clinical Immunology, 1175-1183. |
| Immunocytochemistry: Mouse | ||
| PMID | Dilution | Publication |
| 29129580 | not listed | Rosa, N., et al. 2018. The β and α2δ auxiliary subunits of voltage-gated calcium channel 1 (Cav1) are required for TH2 lymphocyte function and acute allergic airway inflammation. Journal of Allergy and Clinical Immunology, 892-903. |
| 23576958 | 1:200 | Ginger, M., et al. 2013. Three-dimensional tracking and analysis of ion channel signals across dendritic arbors. Frontiers in Neural Circuits, 61. |
| 21674494 | 1:100 | Brandao, K.E., et al. 2012. A-kinase anchoring protein 150 expression in a specific subset of TRPV1- and CaV 1.2-positive nociceptive rat dorsal root ganglion neurons.. Journal of Comparative Neurology, 81-99. |
| 20652277 | not listed | Altomare, C., et al. 2010. Caffeine-induced Ca(2+) signaling as an index of cardiac progenitor cells differentiation.. Basic Research in Cardiology, 737-749. |
| Immunocytochemistry: Rat | ||
| PMID | Dilution | Publication |
| 34431981 | 1:100 | Isensee, J., et al. 2021. Depolarization induces nociceptor sensitization by CaV1.2-mediated PKA-II activation. Journal of Cellular Biology, . |
| 21674494 | 1:100 | Brandao, K.E., et al. 2012. A-kinase anchoring protein 150 expression in a specific subset of TRPV1- and CaV 1.2-positive nociceptive rat dorsal root ganglion neurons.. Journal of Comparative Neurology, 81-99. |
| Immunohistochemistry: Human | ||
| PMID | Dilution | Publication |
| 23771339 | 1:100 | Hurley, M.J., et al. 2013. Parkinson''s disease is associated with altered expression of CaV1 channels and calcium-binding proteins.. Brain, 2077-2097. |
| Immunohistochemistry: Mouse | ||
| PMID | Dilution | Publication |
| 21216955 | not listed | Fu, Y., et al. 2011. Deletion of the distal C terminus of CaV1.2 channels leads to loss of beta-adrenergic regulation and heart failure in vivo.. Journal of Biological Chemistry, 12617-12626. |
| 20826678 | 1:50 | Zorrilla de San Martín, J., et al. 2010. Ca(2+) and Ca(2+)-activated K(+) channels that support and modulate transmitter release at the olivocochlear efferent-inner hair cell synapse.. Journal of Neuroscience, 12157-12167. |
| Immunohistochemistry: Rat | ||
| PMID | Dilution | Publication |
| 23771339 | 1:100 | Hurley, M.J., et al. 2013. Parkinson''s disease is associated with altered expression of CaV1 channels and calcium-binding proteins.. Brain, 2077-2097. |
| 21804529 | 1:200 | Favereaux, A., et al. 2011. Bidirectional integrative regulation of Cav1.2 calcium channel by microRNA miR-103: role in pain. EMBO Journal, 3830-3841. |
| 20089916 | 1:200 | Fossat, P., et al. 2010. Knockdown of L calcium channel subtypes: differential effects in neuropathic pain.. Journal of Neuroscience, 1073-1085. |
| Immunoprecipitation: Human | ||
| PMID | Dilution | Publication |
| 21186355 | 2ug | Altier, C., et al. 2011. The Cavβ subunit prevents RFP2-mediated ubiquitination and proteasomal degradation of L-type channels.. Nature Neuroscience, 173-180. |
| Western Blot: Guinea Pig | ||
| PMID | Dilution | Publication |
| 30075281 | not listed | Zankov, D.P., et al. 2019. Chronic in vivo angiotensin II administration differentially modulates the slow delayed rectifier channels in atrial and ventricular myocytes. Heart Rhythm, 108-116. |
| 23019291 | not listed | Cutler, M.J., et al. 2013. Targeted sarcoplasmic reticulum Ca2+ ATPase 2a gene delivery to restore electrical stability in the failing heart.. Circulation, 2095-2104. |
| 20371314 | not listed | Wang, X., et al. 2010. Phospholemman modulates the gating of cardiac L-type calcium channels.. Biophysical Journal, 1149-1159. |
| Western Blot: Human | ||
| PMID | Dilution | Publication |
| 34163037 | 1:1000 | Rodan, L.H., et al. 2021. Phenotypic expansion of CACNA1C-associated disorders to include isolated neurological manifestations. Genetic Medicine, 19221932. |
| 28049825 | 1:1000 | Caballero, R., et al. 2017. Tbx20 controls the expression of the KCNH2 gene and of hERG channels. PNAS: USA, E416-E425. |
| 25267719 | 1:1000 | Li, L., et al. 2015. Potentiation of high voltage-activated calcium channels by 4-aminopyridine depends on subunit composition.. Molecular Pharmacology, 760-772. |
| 25107449 | 1:1000 | Barana, A., et al. 2015. Chronic atrial fibrillation increases microRNA-21 in human atrial myocytes decreasing L-type calcium current.. Circulation: Arrhythmia and Electrophysiology, 861-868. |
| 23287412 | not listed | Valerie, N.C., et al. 2013. Inhibition of T-type calcium channels disrupts Akt signaling and promotes apoptosis in glioblastoma cells.. Biochem Pharmacol., 888-897. |
| 22891239 | not listed | Wilson, S.M., et al. 2013. Inhibition of transmitter release and attenuation of anti-retroviral-associated and tibial nerve injury-related painful peripheral neuropathy by novel synthetic Ca2+ channel peptides.. Journal of Biological Chemistry, 35065-35077. |
| 22627147 | not listed | Brittain, J.M., et al. 2013. Regulation of CREB signaling through L-type Ca2+ channels by Nipsnap-2.. Channels, 94-102. |
| 19860837 | not listed | Hettiarachchi, N.T., et al. 2009. alpha-Synuclein modulation of Ca2+ signaling in human neuroblastoma (SH-SY5Y) cells.. Journal of Neurochemistry, 1192-1201. |
| Western Blot: Mouse | ||
| PMID | Dilution | Publication |
| 36142639 | 1:10 | Thibault, S., et al. 2022. Higher Na+-Ca2+ Exchanger Function and Triggered Activity Contribute to Male Predisposition to Atrial Fibrillation. International Journal of Molecular Science, 10724. |
| 31822608 | not listed | Hasan, R., et al. 2019. SUMO1 modification of PKD2 channels regulates arterial contractility. PNAS: USA, 27095-27104. |
| 30511640 | 1:100 | Bulley, S., et al. 2018. Arterial smooth muscle cell PKD2 (TRPP1) channels regulate systemic blood pressure. Elife, e42628. |
| 27122098 | 1:200 | Eden, M., et al. 2016. Myoscape controls cardiac calcium cycling and contractility via regulation of L-type calcium channel surface expression. Nature Communications, 11317. |
| 24167226 | 1:1000 | Tajada, S., et al. 2014. Down-regulation of CaV1.2 channels during hypertension: how fewer CaV1.2 channels allow more Ca(2+) into hypertensive arterial smooth muscle.. The Journal of Physiology, 6175-6191. |
| 24033980 | not listed | Núñez‐Santana, F.L., et al. 2014. Surface L-type Ca2+ channel expression levels are increased in aged hippocampus.. Aging Cell, 111-120. |
| 22610174 | 1:500 | LaRocca, T.J., et al. 2012. Na+/Ca2+ exchanger-1 protects against systolic failure in the Akitains2 model of diabetic cardiomyopathy via a CXCR4/NF-κB pathway.. American Journal of Physiology-Heart and Circulatory Physiology, H353-367. |
| 19461043 | not listed | Thomsen, M.B., et al. 2010. Accessory subunit KChIP2 modulates the cardiac L-type calcium current.. Circulation Research, 1382-1289. |
| 18184831 | 1:200 | Télémaque, S., et al. 2008. Design of mutant beta2 subunits as decoy molecules to reduce the expression of functional Ca2+ channels in cardiac cells.. Journal of Pharmacology and Experimental Therapeutics, 37-46. |
| Western Blot: Rabbit | ||
| PMID | Dilution | Publication |
| 20405051 | not listed | Xu, X., et al. 2010. Long-term fish oil supplementation induces cardiac electrical remodeling by changing channel protein expression in the rabbit model.. PLoS One, e10140. |
| Western Blot: Rat | ||
| PMID | Dilution | Publication |
| 27114559 | 1:1000 | Lu, J.M., et al. 2016. GDF-15 enhances intracellular Ca2+ by increasing Cav1.3 expression in rat cerebellar granule neurons. Biochemical Journal, 1895-1904. |
| 25904792 | 1:150 | Kim, H.H., et al. 2015. Costimulation of AMPA and metabotropic glutamate receptors underlies phospholipase C activation by glutamate in hippocampus.. Journal of Neuroscience, 6401-6412. |
| 23568894 | not listed | Bannister, J.P., et al. 2013. The voltage-dependent L-type Ca2+ (CaV1.2) channel C-terminus fragment is a bi-modal vasodilator.. The Journal of Physiology, 2987-2998. |
| 23457553 | 1:4 (supe) | Bissig, D., Goebel, D. and Berkowitz, B.A., et al. 2013. Diminished vision in healthy aging is associated with increased retinal L-type voltage gated calcium channel ion influx.. PLoS One, e56340. |
| 22847236 | not listed | Ramos-Mondragon, R., et al. 2013. Chronic potentiation of cardiac L-type Ca(2+) channels by pirfenidone.. Cardiovascular Research, 244-254. |
| Additional Publications: Unspecified | ||
| PMID | Publication | |
| 21195084 | Bobe, R., et al. 2011. SERCA2a controls the mode of agonist-induced intracellular Ca2+ signal, transcription factor NFAT and proliferation in human vascular smooth muscle cells.. Journal of Molecular and Cellular Cardiology, 621-633. | |