Anti-Beta4-Spectrin Antibody (N393/2)

Name: Anti-Beta4-Spectrin Antibody
Brand: NeuroMab
SKU: 73-376
Price: 345.0 USD
Availability: InStock

from NeuroMab Datasheet

Product Type

Primary Antibody

Species Reactivity

Human, Mouse, Rat

Clone

N393/2

Applications

ICC, IHC, WB

Host Species

Mouse

Format

TC Supernatant

Gene Name

SPTBN4 KIAA1642 SPTBN3

Molecular Weight

>200 kDa

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Immunoblot against extracts of COS cells transfected with tagged Beta- spectrins or untagged Kv2.1 plasmid probed with N393/2 (left) or 19E10 (right) TC supe.

Adult rat cerebral cortex and hippocampus immunohistochemistry with antigen retrieval via pepsin pretreatment.

Immunoblot against extracts of COS cells transfected with tagged Beta- spectrins or untagged Kv2.1 plasmid probed with N393/2 (left) or 19E10 (right) TC supe.

Volume: 5 mL

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Price:

$345

Quantity:

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Product Details

Target

Beta4-spectrin

Target Description

Spectrin beta chain, non-erythrocytic 4, or ß4 spectrin, is a member of the spectrin family of cytoskeletal proteins. It is found in the cytoskeleton and cell cortex of cells in the brain and pancreatic islets. It is also expressed in skeletal muscule. ß4 spectrin functions as a scaffold protein that links the actin cytoskeleton to the plasma membrane. It is involved in cell shape and organization. Mutations in the ß4 spectrin gene are associated with congenital myopathy, and neurodevelopmental disorder with hypotonia, neuropathy and deafness (NEDHND).

Format

TC Supernatant

Concentration

Lot dependent

Clonality

Monoclonal

Clone

N393/2

Isotype

IgG1

Applications

ICC, IHC, WB

Host Species

Mouse

Gene Name

SPTBN4 KIAA1642 SPTBN3

Molecular Weight

>200 kDa

Antigen

Fusion protein amino acids 1621-1832 (C-terminal repeats 14 to 15) of human Beta4-spectrin (accession number Q9H254) produced recombinantly in E. Coli

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2315816

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Supernatant is harvested from hybridoma cells grown under standard cell culture conditions

Buffer

Supernatant is provided in cell culture medium with 0.1% sodium azide as anti-microbial

Conjugate

Unconjugated

Specificity

Does not cross-react with other Beta-spectrins

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Shipping

Shipped on ice packs

Synonyms

Spectrin beta chain, non-erythrocytic 4 (Beta-IV spectrin) (Spectrin, non-erythroid beta chain 3)

UniProt Details

UniProt (Human): Q9H254
UniProt (Immunogen Species): Q9H254

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Anti-Beta4-Spectrin Antibody (N393/2)

Anti-Beta4-Spectrin Antibody
SKU: 73-376

Bulk Order Anti-Beta4-Spectrin Antibody

Product Details

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Anti-Beta4-Spectrin Antibody (N393/2)

Anti-Beta4-Spectrin Antibody SKU: 73-376

Bulk Order Anti-Beta4-Spectrin Antibody

Product Details

Anti-Beta4-Spectrin Antibody
SKU: 73-376