Aldehyde dehydrogenase family 1 member L1 (Aldh1L1) is a member of the aldehyde dehydrogenase family. This protein is an enzyme that catalyzes the conversion of 10-formyltetrahydrofolate, NADP, and water to tetrahydrofolate, NADPH, and carbon dioxide. It is an astrocyte marker and also is expressed in the liver. It is proposed to play a role in regulation of cellular THF levels and inhibiting cell proliferation. Alterations in Aldh1L1 have been implicated in Congenital Hydrocephalus
Protein amino acids 1-902 (full-length) of rat Aldh1L1(also known as 10-formyltetrahydrofolate dehydrogenase, 10-FTHFDH, FBP-CI and Fthfd, accession number P28037); Mouse: 97% identity (875/902 amino acids identical); Human: 91% identity (823/902 amino acids identical); ~70% identity with Aldh1L2
Human, Mouse, Rat
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