Anti-Tyrosine Kinase Receptor C (TrkC) Antibody

Name: Anti-Tyrosine Kinase Receptor C (TrkC) Antibody
Brand: Biosensis
SKU: R-151-100
Price: 327.0 USD
Availability: InStock

Our Anti-Tyrosine Kinase Receptor C (TrkC) rabbit polyclonal primary antibody detects human, mouse, and rat Tyrosine Kinase Receptor C (TrkC), and is whole serum. It is validated for use in IHC-Frozen.

Species Reactivity

Human, Mouse, Rat

Applications

IHC

Host Species

Rabbit

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Data Sheet

SKU: R-151-100

Volume/Size: 100 µL

Variant

Price:

$327.00

Quantity:

Product Details

Target

Tyrosine Kinase Receptor C (TrkC)

Scientific Background

TrkC is a member of the neurotrophic tyrosine receptor kinase family. TrkC is a membrane-bound receptor that upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. TrkC is the receptor for neurotrophin-3 (NT-3). Signalling through TrkC leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. SUBUNIT: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. SUBCELLULAR LOCATION: Membrane; single-pass type I membrane protein. ALTERNATIVE PRODUCTS: 4 named isoforms produced by alternative splicing. Additional isoforms seem to exist. Mutations in TrkC have been associated with medulloblastomas, secretory breast carcinomas and other cancers.

Format

Whole serum

Clonality

Polyclonal

Isotype

Mixed

Applications

IHC

Host Species

Rabbit

Immunogen

Extracellular domain of glycosylated human TrkC protein produced in CHO cells was used as the immunogen.

Immunogen Species

Human

Species Reactivity

Human, Mouse, Rat

Storage

Spin vial briefly before opening. Reconstitute in 100 µL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material. After reconstitution keep aliquots at -20°C for a higher stability, and at 2-8°C with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.

Physical State

Lyophilized

Dilution Ranges

IHC: 1:1000-1:3000

Conjugate

Unconjugated

Specificity

Specificity was demonstrated by immunohistochemistry. This antibody was used to stain cryostat sections of the rat peripheral sensory ganglia. Reacts with human, rat and mouse TrkC. Other species have not yet been tested.

Usage Statement

For research use only.

Country of Origin

United States

Expiration

12 months after date of receipt (unopened vial).

Synonyms

Tropomyosin-related kinase receptor; NT-3 growth factor receptor; Neurotrophic tyrosine kinase receptor type 3; TrkC tyrosine kinase; GP145-TrkC; Trk-C; NTRK3; TRKC

UniProt ID

Q16288

Shipping

25°C (ambient)

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Anti-Tyrosine Kinase Receptor C (TrkC) Antibody

SKU: R-151-100

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