Anti-Tyrosine Kinase Receptor B (TrkB) Antibody

Name: Anti-Tyrosine Kinase Receptor B (TrkB) Antibody
Brand: Biosensis
SKU: R-121-100
Price: 327.0 USD
Availability: InStock

Our Anti-Tyrosine Kinase Receptor B (TrkB) rabbit polyclonal primary antibody detects human, mouse, and rat Tyrosine Kinase Receptor B (TrkB), and is whole serum. It is validated for use in IHC-Frozen.

Immunohistochemical staining of Tyrosine Kinase Receptor B (TrkB) in rat spinal cord using rabbit polyclonal antibody to rat TrkB, catalogue number R-121-100.

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Species Reactivity

Human, Mouse, Rat

Applications

IHC, WB

Host Species

Rabbit

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Data Sheet

SKU: R-121-100

Volume/Size: 100 µL

Variant

Price:

$327.00

Quantity:

Product Details

Target

Tyrosine Kinase Receptor B (TrkB)

Scientific Background

FUNCTION: Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5 but not nerve growth factor (NGF). Involved in the development and/or maintenance of the nervous system. This is a tyrosine-protein kinase receptor. Known substrates for the TRK receptors are SHC1, PI-3 kinase, and PLC-gamma-1. CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. SUBUNIT: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures (By similarity). Binds APS. Interacts with SQSTM1. SUBCELLULAR LOCATION: Membrane; single-pass type I membrane protein. ALTERNATIVE PRODUCTS: 3 named isoforms produced by alternative splicing. Additional isoforms seem to exist. TISSUE SPECIFICITY: The different forms are differentially expressed in various cell types. Isoform T2 is primarily expressed in neurons. PTM: Ligand-mediated auto-phosphorylation. SIMILARITY: Belongs to the Tyr protein kinase family. Insulin receptor subfamily. SIMILARITY: Contains 2 Ig-like C2-type (immunoglobulin-like) domains. SIMILARITY: Contains 2 LRR (leucine-rich) repeats. SIMILARITY: Contains 1 protein kinase domain.

Format

Whole serum

Clonality

Polyclonal

Isotype

Mixed

Applications

IHC, WB

Host Species

Rabbit

Immunogen

A synthetic peptide (AFPRLEPNSIDPEN(C)) as part of rat TrkB protein (aa: 54-67) conjugated to KLH

Immunogen Species

Rat

Species Reactivity

Human, Mouse, Rat

Storage

Spin vial briefly before opening. Reconstitute in 100 µL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material. After reconstitution keep aliquots at -20°C for a higher stability, and at 2-8°C with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.

Physical State

Lyophilized

Dilution Ranges

WB: 1:500-1:1000
IHC: 1:1000-1:3000

Application Details

The sequence of the immunogen and the conjugate are identical to the one used by Yan et al (see the Refs) and the antiserum appears to have similar characteristics.

Conjugate

Unconjugated

Specificity

Sequence was chosen to avoid cross reactivity with TrkA and TrkC. This antiserum recognizes human, rat and mouse TrkB. Cross reactivity with other species has not yet been tested.

Usage Statement

For research use only.

Country of Origin

United States

Expiration

12 months after date of receipt (unopened vial).

Synonyms

Tropomyosin-related kinase receptor; BDNF/NT-3 growth factors receptor; Neurotrophic tyrosine kinase receptor type 2; TrkB tyrosine kinase; GP145-TrkB/GP95-TrkB; Trk-B; Ntrk2; Trkb

UniProt ID

Q63604

Shipping

25°C (ambient)

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Anti-Tyrosine Kinase Receptor B (TrkB) Antibody

SKU: R-121-100

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