Anti-Superoxide dismutase 1 (SOD1) Antibody

Name: Anti-Superoxide dismutase 1 (SOD1) Antibody
Brand: Biosensis
SKU: R-126-100
Price: 327.0 USD
Availability: InStock

Our Anti-Superoxide dismutase 1 (SOD1) rabbit polyclonal primary antibody detects mouse and rat Superoxide dismutase 1 (SOD1), and is whole serum. It is validated for use in WB.

Western blot detection of mouse SOD1 in mouse brain tissue extract (lane 1) when using Rabbit antibody to mouse superoxide dismutase (SOD1; 24-36): whole serum (catalogue no. R-126-100) at a dilution of 1:500. The immunoreactivity of this antibody is completely abolished when it is pre-incubated with the immunising SOD1 peptide (lane 2).

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Species Reactivity

Mouse, Rat

Applications

Host Species

Rabbit

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Data Sheet

SKU: R-126-100

Volume/Size: 100 µL

Variant

Price:

$327.00

Quantity:

Product Details

Target

Superoxide dismutase 1 (SOD1)

Scientific Background

FUNCTION: Destroys radicals which are normally produced within the cells and which are toxic to biological systems. CATALYTIC ACTIVITY: 2 superoxide + 2 H+ = O2 + H2O2. COFACTOR: Binds 1 copper ion per subunit. COFACTOR: Binds 1 zinc ion per subunit. SUBUNIT: Homodimer. SUBCELLULAR LOCATION: Cytoplasm. DISEASE: Defects in SOD1 are the cause of familial amyotrophic lateral sclerosis (FALS); also called amyotrophic lateral sclerosis 1 (ALS1 or ALS). ALS is a degenerative disorder of motorneurons in the cortex, brainstem and spinal cord. ALS is characterized by muscular weakness and atrophy beginning in the hands and spreading to the forearms and legs. Muscle fasciculations are commonly visible. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. ALS is sometimes referred to as Lou Gehrig disease after the famous American baseball player who was diagnosed with the disorder. FALS, the familial form of ALS, accounts for about 10% of the cases and is transmitted in an autosomal dominant manner. The mean age at onset of FALS is 45 years. MISCELLANEOUS: Zinc binding promotes dimerization. SIMILARITY: Belongs to the Cu-Zn superoxide dismutase family.

Format

Whole serum

Clonality

Polyclonal

Isotype

Mixed

Applications

Host Species

Rabbit

Immunogen

A synthetic peptide (ASGEPVV LSGQIT) as part of mouse superoxide dismutase (SOD1) protein (aa: 24-36) conjugated to diphtheria toxoid

Immunogen Species

Mouse

Species Reactivity

Mouse, Rat

Storage

Spin vial briefly before opening. Reconstitute in 100 µL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material. After reconstitution keep aliquots at -20°C for a higher stability, and at 2-8°C with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.

Physical State

Lyophilized

Dilution Ranges

WB: 1:500-1:1000

Conjugate

Unconjugated

Specificity

Specificity was confirmed by Western blot detecting mouse superoxide dismutase (SOD1). This antiserum is known to react with mouse and rat superoxide dismutase (SOD1) protein.

Usage Statement

For research use only.

Country of Origin

United States

Expiration

12 months after date of receipt (unopened vial).

Synonyms

Superoxide dismutase [Cu-Zn]; SOD1

UniProt ID

P08228

Shipping

25°C (ambient)

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Anti-Superoxide dismutase 1 (SOD1) Antibody

SKU: R-126-100

Product Details

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