Our Neuromab PSD-95 antibody is KO validated and is the most highly-cited PSD-95 antibody for IHC, ICC, & WB!


Immunofluorescence of cultured rat hippocampal neurons labeled with PSD-95 (green, cat. 75-028) and Kv4.2 (red, cat. 75-016).

Found at postsynaptic densities of excitatory neurons, PSD-95 plays an important role in synaptic plasticity and the stabilization of synaptic changes during long-term potentiation.

Encoded by DLG4, Postsynaptic Density Protein-95 (PSD-95) functions as a major scaffold protein that can cluster membrane receptors, ion channels, including NMDA receptor subunits, Kv1 potassium channels and Caspr2. PSD-95 has the unique ability to interact with a large number of proteins through three PDZ domains, followed by SH3 and GK domains. PSD-95 is highly regulated by phosphorylation. PSD-95 disruption has been associated with cognitive and learning deficits such as Alzheimer’s, depression, schizophrenia, and autism.


Western blot of adult rat brain membranes (RBM) and adult mouse hippocampal membranes (MHM) from PSD-95 and -93 knockout (KO) mice probed with PSD-95 (cat. 75-028). Mouse samples courtesy of Richard Huganir (Johns Hopkins University, Howard Hughes Medical Institute). 

Check out the most recent publications using our PSD-95 antibody below!

Product Specific References for Applications and Species

Selected PSD-95 Publications from 2022. View all citations here.
Application: Species Dilution Publication
ICC: human 1:1000 Murtaza, N., et al. 2022. Neuron-Specific Protein Network Mapping Of Autism Risk Genes Identifies Shared Biological Mechanisms And Disease-Relevant Pathologies. Cell Reports.
ICC: mouse 1:200 Joshi, D.C., et al. 2022. Tripartite Crosstalk Between Cytokine IL-1β, NMDA-R and Misplaced Mitochondrial Anchor in Neuronal Dendrites is a Novel Pathway for Neurodegeneration in Inflammatory Diseases. The Journal of Neuroscience.
ICC: rat 1:1000 Kozlova, A., et al. 2022. Loss of function of OTUD7A in the schizophrenia- associated 15q13.3 deletion impairs synapse development and function in human neurons. American Journal of Human Genetics.
IHC: mouse 1:500 El Chehadeh, S., et al. 2022. SLITRK2 Variants Associated with Neurodevelopmental Disorders Impair Excitatory Synaptic Function and Cognition in Mice. Nature Communications.
IHC: rat 1:150 Simonsen, Ø.W., et al. 2022. Retrosplenial and Subicular Inputs Converge on Superficially Projecting Layer V Neurons of Medial Entorhinal Cortex. Brain Structure & Function.
IP: mouse 0.5mg/ml Barisano, G., et al. 2022. A "Multi-omics" Analysis of Blood-Brain Barrier and Synaptic Dysfunction in APOE4 Mice. The Journal of Experimental Medicine.
WB: human 1:1000 Ifrim, M.F., et al. 2022. Development Of Single-Molecule Ubiquitination Mediated Fluorescence Complementation To Visualize Protein Ubiquitination Dynamics In Dendrites. Cell Reports.
WB: mouse 1:1000 Mendoza, M.L., et al. 2022. KIBRA Regulates Activity-Induced AMPA Receptor Expression And Synaptic Plasticity In An Age-Dependent Manner. Iscience.
WB: rat 1:500 Rodriguez-Ortiz, C.J., et al. 2022. Angiotensin Receptor Blockade With Olmesartan Alleviates Brain Pathology In Obese OLETF Rats. Clinical And Experimental Pharmacology & Physiology.