Anti-Tyrosine Hydroxylase Antibody (Purified) (LNC1)
Our Anti-Tyrosine Hydroxylase (TH) mouse monoclonal primary antibody from Aves Labs is produced in-house. It detects chicken, frog, human, lizard, monkey, mouse, rat, vole, and zebrafish Tyrosine Hydroxylase (TH), and is purified. It is great for use in WB, IC, IHC, IP.
Chicken, Frog, Human, Lizard, Mouse, Non-Human Primate, Rat, Vole, Zebrafish
ICC, IHC, IP, WB
Mouse
Trial Size
SKU: LNC1-P
Product Details
Tyrosine Hydroxylase (TH)
Tyrosine Hydroxylase (TH) is the rate-limiting enzyme in the synthesis of the catecholamine neurotransmitters dopamine, epinephrine, and norepinephrine and is responsible for converting L-tyrosine to L-dopa. Synthesis of catecholamines is regulated by the interaction of TH with its cofactor, tetrahydrobiopterin (BH4), and the substrates L-tyrosine and molecular oxygen. In humans, four TH mRNA splice variants (hTH1-hTH4) have been isolated, while subprimate species rely on a single form of TH. It is known that the hTH1-hTH4 variants are identical in their catalytic domain but differ in their N-terminal regulatory domains. Importantly, LNC1 reacts with the catalytic domain of TH and thus with all four isoforms of human TH. The role of TH in the synthesis of catecholamine neurotransmitters suggests a connection between the enzyme and a number of neuropathogenic diseases characterized by irregular catecholamine levels, such as Parkinson's disease, schizophrenia, and dystonia, as well as a variety of cardiovascular diseases.
Purified (Anti-Tyrosine Hydroxylase Antibody LNC1 clone is also available in ascites form.)
1 mg/mL
Monoclonal
LNC1
IgG1
ICC, IHC, IP, WB
Mouse
TH, TYH, EC 1.14.16.2
59-63 kDa
Tyrosine Hydroxylase purified from PC12 cells
Chicken, Frog, Human, Lizard, Mouse, Non-Human Primate, Rat, Vole, Zebrafish
AB_2201528
Aliquot and store at -20 degrees celcius. Stable for 2 years after opening when stored as described.
Liquid
Purified by Protein A chromatography
10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.4
WB: 1:1000
IHC: 1:1000
ICC: 1:500-1:1000
IHC: 1:1000
ICC: 1:500-1:1000
Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
United States
12 months from receipt of product
Ice packs
Tyrosine 3-monooxygenase
UniProt (Human): P07101
UniProt (Immunogen Species): P07101
UniProt (Immunogen Species): P07101