Anti-Potassium Chloride Cotransporter (KCC2) (Ser940) Antibody

Our Anti-Potassium Chloride Cotransporter (KCC2) (Ser940) rabbit polyclonal phosphospecific primary antibody from PhosphoSolutions is produced in-house. It detects mouse and rat Potassium Chloride Cotransporter (KCC2) (Ser940) and is antigen affinity purified from pooled serum. It is great for use in WB, IP.

SKU: p1551-940

Volume: 100 µL
Sale price$430.00

Product Specific References for Applications and Species

Immunoprecipitation: Mouse
PMID Dilution Publication
29028184 20-100ug of antibody per 1-10mg lysate Mahadevan, V., et al. 2017. Native KCC2 interactome reveals PACSIN1 as a critical regulator of synaptic inhibition. Elife, 6, p.e28270.
Western Blot: Mouse
PMID Dilution Publication
376885741:5000Liao, W, et al. 2023. CDKL5-mediated developmental tuning of neuronal excitability and concomitant regulation of transcriptome. Human Molecular Genetics, .
368893191:1000Jarvis, R., et al. 2023. Direct Activation of KCC2 Arrests Benzodiazepine Refractory Status Epilepticus and Limits the Subsequent Neuronal Injury in Mice. Cell Reports Medicine, 100957.
31308096 1:1000 Gomez, C.D., et al. 2019. Early life inflammation increases CA1 pyramidal neuron excitability in a sex and age dependent manner through a chloride homeostasis disruption. Journal of Neuroscience, pp.2973-18.
30689208 1:1000 Mekhael, W., et al. 2019. Repeated anodal trans‐spinal direct current stimulation results in long‐term reduction of spasticity in mice with spinal cord injury. The Journal of physiology, Apr;597(8):2201-2223.
29028184 not listed Mahadevan, V., et al. 2017. Native KCC2 interactome reveals PACSIN1 as a critical regulator of synaptic inhibition. Elife, 6, p.e28270.
28683314 not listed Ruinetti-Vargas, G., et al. 2017. Periadolescent Maturation of GABAergic Hyperpolarization at the Axon Initial Segment. Cell Reports, 20(1), pp.21-29.
25733865 not listed Silayeva, L., et al. 2015. KCC2 activity is critical in limiting the onset and severity of status epilepticus. PNAS. Mar 2. pii: 201415126.
24478630 1:1000 Mòdol, L., et al. 2014. Differential effects on KCC2 expression and spasticity of ALS and traumatic injuries to motoneurons. Frontiers in cellular neuroscience, Jan 24; 8:7.
22171026 1:1000 Sarkar, J., et al. 2011. Neurosteroidogenesis is required for the physiological response to stress: role of neurosteroid-sensitive GABAA receptors. J Neurosci. 31(50):18198-210.
Western Blot: Rat
PMID Dilution Publication
364010601:1000Zhang, H., et al. 2022. Role Of KCC2 In The Regulation Of Brain-Derived Neurotrophic Factor On Ethanol Consumption In Rats. Molecular Neurobiology, .
35352582 1:1000 Gao, Y., et al. 2022. KCC2 receptor upregulation potentiates antinociceptive effect of GABAAR agonist on remifentanil-induced hyperalgesia. Molecular pain, 18, p.17448069221082880.
34833037 1:1000 Kalashnikov, V.E., et al. 2021. Prochlorperazine Withdraws the Delayed Onset Tonic Activity of Unloaded Rat Soleus Muscle: A Pilot Study. Life, 11(11), p.1161.
33257295 1:1000 Kwon, H.H., et al. 2020. Vitamin E reduces spasms caused by prenatal stress by lowering calpain expression. Epilepsy & Behavior, p.107609.
29729247 1:1000 Huang, Y.J., et al. 2018. Ionic plasticity and pain: the loss of descending serotonergic fibers after spinal cord injury transforms how GABA affects pain. Experimental Neurology, 306, pp.105-116.
29092909 1:1000 Conway, L.C., et al. 2017. N-ethylmaleimide increases KCC2 activity by modulating transporter phosphorylation. Journal of Biological Chemistry, Dec 29;292(52):21253-21263.
27639636 1:1000 Huang, Y.J., et al. 2016. Acute spinal cord injury (SCI) transforms how GABA affects nociceptive sensitization. Experimental Neurology, 285, pp.82-95.
26090759 1:1000 López-Álvarez, V. M., et al. 2015. Early increasing-intensity treadmill exercise reduces neuropathic pain by preventing nociceptor collateral sprouting and disruption of chloride cotransporters homeostasis after peripheral nerve injury. Pain. Jun 18.
24861264 1:1000 Mòdol, L., et al. 2014. Neonatal allopregnanolone or finasteride administration modifies hippocampal K+ Cl− co-transporter expression during early development in male rats. The Journal of steroid biochemistry and molecular biology, Sep; 143:343-7.
24813295 1:1000 Mòdol, L., et al. 2014. Prevention of NKCC1 phosphorylation avoids downregulation of KCC2 in central sensory pathways and reduces neuropathic pain after peripheral nerve injury. PAIN, Aug; 155(8):1577-90.
21532577 not listed Lee, H.H., et al. 2014. NMDA receptor activity downregulates KCC2 resulting in depolarizing GABAA receptor-mediated currents. Nat Neurosci. Jun;14(6):736-43.

Product Specific Protocols

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