Anti-Potassium Chloride Cotransporter (KCC2) (Ser940) Antibody


Our Anti-Potassium Chloride Cotransporter (KCC2) (Ser940) rabbit polyclonal phosphospecific primary antibody from PhosphoSolutions is produced in-house. It detects mouse and rat Potassium Chloride Cotransporter (KCC2) (Ser940) and is antigen affinity purified from pooled serum. It is great for use in WB, IP.

Primary Antibody
Rat
Bovine, Canine, Non-Human Primate, Zebrafish
IP, WB
Rabbit
Antigen Affinity Purified from Pooled Serum
KCC2
135 kDa

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Anti-Potassium Chloride Cotransporter (KCC2) (Ser940) Antibody
SKU: p1551-940

Volume: 100 µL
Price:
Sale price$390


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Product Specific References for Applications and Species

Immunoprecipitation: Mouse
PMID Dilution Publication
29028184 20-100ug of antibody per 1-10mg lysate Mahadevan, V., et al. 2017. Native KCC2 interactome reveals PACSIN1 as a critical regulator of synaptic inhibition. Elife, 6, p.e28270.
Western Blot: Mouse
PMID Dilution Publication
31308096 1:1000 Gomez, C.D., et al. 2019. Early life inflammation increases CA1 pyramidal neuron excitability in a sex and age dependent manner through a chloride homeostasis disruption. Journal of Neuroscience, pp.2973-18.
30689208 1:1000 Mekhael, W., et al. 2019. Repeated anodal trans‐spinal direct current stimulation results in long‐term reduction of spasticity in mice with spinal cord injury. The Journal of physiology, Apr;597(8):2201-2223.
29028184 not listed Mahadevan, V., et al. 2017. Native KCC2 interactome reveals PACSIN1 as a critical regulator of synaptic inhibition. Elife, 6, p.e28270.
28683314 not listed Ruinetti-Vargas, G., et al. 2017. Periadolescent Maturation of GABAergic Hyperpolarization at the Axon Initial Segment. Cell Reports, 20(1), pp.21-29.
25733865 not listed Silayeva, L., et al. 2015. KCC2 activity is critical in limiting the onset and severity of status epilepticus. PNAS. Mar 2. pii: 201415126.
24478630 1:1000 Mòdol, L., et al. 2014. Differential effects on KCC2 expression and spasticity of ALS and traumatic injuries to motoneurons. Frontiers in cellular neuroscience, Jan 24; 8:7.
22171026 1:1000 Sarkar, J., et al. 2011. Neurosteroidogenesis is required for the physiological response to stress: role of neurosteroid-sensitive GABAA receptors. J Neurosci. 31(50):18198-210.
Western Blot: Rat
PMID Dilution Publication
35352582 1:1000 Gao, Y., et al. 2022. KCC2 receptor upregulation potentiates antinociceptive effect of GABAAR agonist on remifentanil-induced hyperalgesia. Molecular pain, 18, p.17448069221082880.
34833037 1:1000 Kalashnikov, V.E., et al. 2021. Prochlorperazine Withdraws the Delayed Onset Tonic Activity of Unloaded Rat Soleus Muscle: A Pilot Study. Life, 11(11), p.1161.
33257295 1:1000 Kwon, H.H., et al. 2020. Vitamin E reduces spasms caused by prenatal stress by lowering calpain expression. Epilepsy & Behavior, p.107609.
29729247 1:1000 Huang, Y.J., et al. 2018. Ionic plasticity and pain: the loss of descending serotonergic fibers after spinal cord injury transforms how GABA affects pain. Experimental Neurology, 306, pp.105-116.
29092909 1:1000 Conway, L.C., et al. 2017. N-ethylmaleimide increases KCC2 activity by modulating transporter phosphorylation. Journal of Biological Chemistry, Dec 29;292(52):21253-21263.
27639636 1:1000 Huang, Y.J., et al. 2016. Acute spinal cord injury (SCI) transforms how GABA affects nociceptive sensitization. Experimental Neurology, 285, pp.82-95.
26090759 1:1000 López-Álvarez, V. M., et al. 2015. Early increasing-intensity treadmill exercise reduces neuropathic pain by preventing nociceptor collateral sprouting and disruption of chloride cotransporters homeostasis after peripheral nerve injury. Pain. Jun 18.
24861264 1:1000 Mòdol, L., et al. 2014. Neonatal allopregnanolone or finasteride administration modifies hippocampal K+ Cl− co-transporter expression during early development in male rats. The Journal of steroid biochemistry and molecular biology, Sep; 143:343-7.
24813295 1:1000 Mòdol, L., et al. 2014. Prevention of NKCC1 phosphorylation avoids downregulation of KCC2 in central sensory pathways and reduces neuropathic pain after peripheral nerve injury. PAIN, Aug; 155(8):1577-90.
21532577 not listed Lee, H.H., et al. 2014. NMDA receptor activity downregulates KCC2 resulting in depolarizing GABAA receptor-mediated currents. Nat Neurosci. Jun;14(6):736-43.

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