Anti-Kv4.2 K+ Channel Antibody (K57/1)


Primary Antibody
Human, Mouse, Rat
K57/1
ICC, IHC, IP, WB
Mouse
Purified
KCND2 KIAA1044
75-80 kDa

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Anti-Kv4.2 K+ Channel Antibody
SKU: 75-016

Volume: 100 µL
Price:
Sale price$361


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Product Specific References for Applications and Species

Array Tomography: Rat
PMID Dilution Publication
264009491:300Simkin, D., et al. 2015. Aging-related hyperexcitability in CA3 pyramidal neurons is mediated by enhanced A-type K+ channel function and expression. . Journal of Neuroscience, 13206-13218.
Electron Microscopy: Mouse
PMID Dilution Publication
350453071:25Murphy, J.G., et al. 2022. R-type voltage-gated Ca2+ channels mediate A-type K+ current regulation of synaptic input in hippocampal dendrites. Cell reports, 110264.
Histoblotting: Mouse
PMID Dilution Publication
30634540not listedAlfaro-Ruíz, R., et al. 2019. Expression, cellular and subcellular localisation of Kv4. 2 and Kv4. 3 channels in the rodent hippocampus. . International journal of molecular sciences, 246.
Immunocytochemistry: Human
PMID Dilution Publication
312120131:100Tabor, G.T., et al. 2019. A novel bungarotoxin binding site-tagged construct reveals MAPK-dependent Kv4. 2 trafficking.. Molecular and Cellular Neuroscience, 121-130.
Immunocytochemistry: Mouse
PMID Dilution Publication
322184351:200Hu, J.H., et al. 2020. Activity-dependent isomerization of Kv4. 2 by Pin1 regulates cognitive flexibility. . Nature communications, 1-18.
298021971:10Cheng, L., et al. 2018. Coupling of Smoothened to inhibitory G proteins reduces voltage-gated K+ currents in cardiomyocytes and prolongs cardiac action potential duration. . Journal of Biological Chemistry, 11022-11032.
Immunocytochemistry: Rat
PMID Dilution Publication
355081861:200Li, Y., et al. 2022. Kv4. 2 phosphorylation by PKA drives Kv4. 2-KChIP2 dissociation, leading to Kv4. 2 out of lipid rafts and internalization.. American Journal of Physiology-Cell Physiology, C190-C201.
355081861:200Li, Y., et al. 2022. Kv4.2 phosphorylation by PKA drives Kv4.2 - KChIP2 dissociation, leading to Kv4.2 out of lipid rafts and internalization. American journal of physiology. Cell physiology, C190-C201.
26456351 1 : 500Gupte, R.P., et al. 2016. Convergent phosphomodulation of the major neuronal dendritic potassium channel Kv4.2 by pituitary adenylate cyclase-activating polypeptide.. Neuropharmacology, 291-308.
245699931:200Jensen, C.S., et al. 2014. Specific sorting and post-Golgi trafficking of dendritic potassium channels in living neurons.. The Journal of Biological Chemistry, 10566-10581.
23836929not listedSosanya, N.M., et al. 2013. Degradation of high affinity HuD targets releases Kv1.1 mRNA from miR-129 repression by mTORC1.. The Journal of Biology, 53-69.
23836929not listedSosanya, N.M., et al. 2013. Degradation of high affinity HuD targets releases Kv1.1 mRNA from miR-129 repression by mTORC1.. The Journal of Biology, 53-69.
Immunohistochemistry: Mouse
PMID Dilution Publication
33789707not listedRhee, J.K., et al. 2021. Projection-dependent heterogeneity of cerebellar granule cell calcium responses.. Molecular brain, 1-17.
328246771:200Hu, J.H., et al. 2020. P38 Regulates kainic acid-induced seizure and neuronal firing via Kv4. 2 phosphorylation. . International Journal of Molecular Sciences, 5921.
32822706not listedTiwari, D., et al. 2020. The potassium channel Kv4. 2 regulates dendritic spine morphology, electroencephalographic characteristics and seizure susceptibility in mice.. Experimental Neurology, 113437.
31509753not listedPark, H., et al. 2019. Inputs from sequentially developed parallel fibers are required for cerebellar organization.. Cell Reports, 2939-2954.
30634540not listedAlfaro-Ruíz, R., et al. 2019. Expression, cellular and subcellular localisation of Kv4. 2 and Kv4. 3 channels in the rodent hippocampus. . International journal of molecular sciences, 246.
23940262not listedSack, J.T., et al. 2013. Antibody-guided photoablation of voltage-gated potassium currents.. The Journal of General Physiology, 315-324.
22612819not listedMenegola, M., et al. 2012. The importance of immunohistochemical analyses in evaluating the phenotype of Kv channel knockout mice.. Epilepsia, 142-149.
Immunohistochemistry: Rat
PMID Dilution Publication
32899153not listedAlfaro-Ruíz, R., et al. 2020. Cellular and subcellular localisation of kv4-associated kchip proteins in the rat cerebellum. . International journal of molecular sciences, 6403.
278071631:500Rizwan, A.P., et al. 2016. Long-Term potentiation at the mossy fiber–granule cell relay invokes postsynaptic second-messenger regulation of Kv4 channels.. Journal of Neuroscience, 11196-11207.
264563511 : 500Schilling, J.M., et al. 2016. Convergent phosphomodulation of the major neuronal dendritic potassium channel Kv4.2 by pituitary adenylate cyclase-activating polypeptide.. Neuropharmacology, 291-308.
264009491:500Simkin, D., et al. 2015. Aging-related hyperexcitability in CA3 pyramidal neurons is mediated by enhanced A-type K+ channel function and expression. . Journal of Neuroscience, 13206-13218.
24037673not listedRainnie, D.G., et al. 2014. Distribution and functional expression of Kv4 family α subunits and associated KChIP β subunits in the bed nucleus of the stria terminalis.. Journal of Comparative Neurology, 609-25.
24037673not listedRainnie, D.G., et al. 2014. Distribution and functional expression of Kv4 family α subunits and associated KChIP β subunits in the bed nucleus of the stria terminalis.. Journal of Comparative Neurology, 609-25.
228201701:100Matsuyoshi, H., et al. 2012. Distinct cellular distributions of Kv4 pore-forming and auxiliary subunits in rat dorsal root ganglion neurons.. Life Sciences, 258-263.
22675541not listedManning, C.F., et al. 2012. Benefits and pitfalls of secondary antibodies: why choosing the right secondary is of primary importance.. PLoS One, e38313.
Immunoprecipitation: Mouse
PMID Dilution Publication
322184352-3 ugHu, J.H., et al. 2020. Activity-dependent isomerization of Kv4. 2 by Pin1 regulates cognitive flexibility. . Nature communications, 1-18.
29306897not listedHuang, L., et al. 2018. Critical roles of Xirp proteins in cardiac conduction and their rare variants identified in sudden unexplained nocturnal death syndrome and Brugada syndrome in Chinese Han population. . Journal of the American Heart Association, e006320.
Immunoprecipitation: Rat
PMID Dilution Publication
26456351 1 : 200Gupte, R.P., et al. 2016. Convergent phosphomodulation of the major neuronal dendritic potassium channel Kv4.2 by pituitary adenylate cyclase-activating polypeptide.. Neuropharmacology, 291-308.
Western Blot: Human
PMID Dilution Publication
312120131:2000Tabor, G.T., et al. 2019. A novel bungarotoxin binding site-tagged construct reveals MAPK-dependent Kv4. 2 trafficking.. Molecular and Cellular Neuroscience, 121-130.
285603111:500Hermanstyne, T.O., et al. 2017. Acute knockdown of Kv4. 1 regulates repetitive firing rates and clock gene expression in the suprachiasmatic nucleus and daily rhythms in locomotor behavior. . Eneuro, .
285603111:500Hermanstyne, T.O., et al. 2017. Acute knockdown of Kv4. 1 regulates repetitive firing rates and clock gene expression in the suprachiasmatic nucleus and daily rhythms in locomotor behavior. . Eneuro, .
251908071:2000Lin, L., et al. 2014. DPP6 domains responsible for its localization and function.. The Journal of Biological Chemistry, 32153-32165.
Western Blot: Mouse
PMID Dilution Publication
364276901:1000Aceto, G., et al. 2022. Acute Restraint Stress Impairs Histamine Type 2 Receptor Ability To Increase The Excitability Of Medium Spiny Neurons In The Nucleus Accumbens. Neurobiology Of Disease, 105932.
34910912not listedYokoi, N., et al. 2021. 14-3-3 proteins stabilize LGI1-ADAM22 levels to regulate seizure thresholds in mice. Cell Reports, 110107.
328246771:2000Hu, J.H., et al. 2020. P38 Regulates kainic acid-induced seizure and neuronal firing via Kv4. 2 phosphorylation. . International Journal of Molecular Sciences, 5921.
32822706not listedTiwari, D., et al. 2020. The potassium channel Kv4. 2 regulates dendritic spine morphology, electroencephalographic characteristics and seizure susceptibility in mice.. Experimental Neurology, 113437.
322184351:2000Hu, J.H., et al. 2020. Activity-dependent isomerization of Kv4. 2 by Pin1 regulates cognitive flexibility. . Nature communications, 1-18.
31212067not listedTiwari, D., et al. 2019. MicroRNA inhibition upregulates hippocampal A-type potassium current and reduces seizure frequency in a mouse model of epilepsy. . Neurobiology of disease, 104508.
310175731:1000Carrillo-Reid, L., et al. 2019. Mutant huntingtin enhances activation of dendritic Kv4 K+ channels in striatal spiny projection neurons.. Elife, e40818.
29306897not listedHuang, L., et al. 2018. Critical roles of Xirp proteins in cardiac conduction and their rare variants identified in sudden unexplained nocturnal death syndrome and Brugada syndrome in Chinese Han population. . Journal of the American Heart Association, e006320.
27023865not listedSchilling, J.M., et al. 2016. Electrophysiology and metabolism of caveolin-3-overexpressing mice. . Basic research in cardiology, 1-13.
247955611:1000Lugo, J.N., et al. 2014. Deletion of PTEN produces autism-like behavioral deficits and alterations in synaptic proteins.. Frontiers in Molecular Neuroscience, 27.
243756411:200Lopez-Izquierdo, A., et al. 2014. The absence of insulin signaling in the heart induces changes in potassium channel expression and ventricular repolarization.. American Journal of Physiology-Heart and Circulatory Physiology, H747-H754.
24225951not listedMercer, R.C., et al. 2013. The prion protein modulates A-type K+ currents mediated by Kv4.2 complexes through dipeptidyl aminopeptidase-like protein 6.. The Journal of Biological Chemistry, 37241-37255.
23940262not listedSack, J.T., et al. 2013. Antibody-guided photoablation of voltage-gated potassium currents.. The Journal of General Physiology, 315-324.
22539834not listedMarionneau, C., et al. 2012. The sodium channel accessory subunit Navβ1 regulates neuronal excitability through modulation of repolarizing voltage-gated K⁺ channels.. Journal of Neuroscience, 5716-5727.
22311982not listedFoeger, N.C., et al. 2012. Augmentation of Kv4.2-encoded currents by accessory dipeptidyl peptidase 6 and 10 subunits reflects selective cell surface Kv4.2 protein stabilization.. The Journal of Biological Chemistry, 9640-9650.
Western Blot: Rat
PMID Dilution Publication
29996472not listedKashino, Y., et al. 2018. ERK5 Phosphorylates K v 4.2 and Inhibits Inactivation of the A-Type Current in PC12 Cells. International Journal of Molecular Sciences, 2008.
29881800not listedLai, Y.C., et al. 2018. Myocardial remodeling and susceptibility to ventricular tachycardia in a model of chronic epilepsy. . Epilepsia open, 213-223.
29881800not listedLai, Y.C., et al. 2018. Myocardial remodeling and susceptibility to ventricular tachycardia in a model of chronic epilepsy. . Epilepsia open, 213-223.
275550911:1000Brewster, A.L., et al. 2016. Early cardiac electrographic and molecular remodeling in a model of status epilepticus and acquired epilepsy. . Epilepsia, 1907-1915.
272590671:1000Lei, Z., et al. 2016. Reduced expression of IA channels is associated with post-ischemic seizures.. Epilepsy Research, 40-48.
271471181:1000Spencer, K.B., et al. 2016. FMRP mediates chronic ethanol‐induced changes in NMDA, Kv4. 2, and KChIP3 expression in the hippocampus. . Alcoholism: Clinical and Experimental Research, 1251-1261.
264563511 : 1000Gupte, R.P., et al. 2016. Convergent phosphomodulation of the major neuronal dendritic potassium channel Kv4.2 by pituitary adenylate cyclase-activating polypeptide.. Neuropharmacology, 291-308.
264009491 : 1000Simkin, D., et al. 2015. Aging-related hyperexcitability in CA3 pyramidal neurons is mediated by enhanced A-type K+ channel function and expression. . Journal of Neuroscience, 13206-13218.
255108581:1000Mulholland, P.J., et al. 2015. Neuroplasticity of A-type potassium channel complexes induced by chronic alcohol exposure enhances dendritic calcium transients in hippocampus.. Psychopharmacology, 1995-2006.
23940262not listedSack, J.T., et al. 2013. Antibody-guided photoablation of voltage-gated potassium currents.. The Journal of General Physiology, 315-324.
235367711:1000Brewster, A.L., et al. 2013. Rapamycin reverses status epilepticus-induced memory deficits and dendritic damage.. PLoS One, e57808.
230660171:2000Yao, J.J., et al. 2012. Neuritin activates insulin receptor pathway to up-regulate Kv4.2-mediated transient outward K+ current in rat cerebellar granule neurons.. The Journal of Biological Chemistry, 41534-41545.
Additional Publications: Unspecified
PMID Publication
29524214Shiotani, H., et al. 2018. Localization of nectin‐2α at the boundary between the adjacent somata of the clustered cholinergic neurons and its regulatory role in the subcellular localization of the voltage‐gated A‐type K+ channel Kv4. 2 in the medial habenula. . Journal of Comparative Neurology, 1527-1549.
25182224Jensen, C.S., et al. 2014. Live-cell imaging of post-golgi transport vesicles in cultured hippocampal neurons.. Cell Molecular Neurobiology, 123-135.
24723263Dufour, M.A., et al. 2014. Somatodendritic ion channel expression in substantia nigra pars compacta dopaminergic neurons across postnatal development.. Journal of Neuroscience Research, 981-999.
23703525Yao, J.J., et al. 2013. Neuregulin-1/ErbB4 signaling regulates Kv4.2-mediated transient outward K+ current through the Akt/mTOR pathway.. American Journal of Physiology-Cell Physiology, C197-C206.
22932868Kaufmann, W.A., et al. 2013. Kv4.2 potassium channels segregate to extrasynaptic domains and influence intrasynaptic NMDA receptor NR2B subunit expression.. Brian Structure and Function, 1115-1132.
22833396Xu, D., et al. 2013. Butyrate-induced colonic hypersensitivity is mediated by mitogen-activated protein kinase activation in rat dorsal root ganglia.. Gut, 1466-1474.
23055512Kim, E., et al. 2012. Dynamic regulation of synaptic maturation state by voltage-gated A-type K+ channels in CA1 hippocampal pyramidal neurons.. Journal of Neuroscience, 14427-14432.
22122031Smith, S.E., et al. 2012. Mutant LGI1 inhibits seizure-induced trafficking of Kv4.2 potassium channels.. Journal of Neurochemistry, 611-621.
21676499Wykes, R., et al. 2012. Changes in the physiology of CA1 hippocampal pyramidal neurons in preplaque CRND8 mice. . Neurobiology of aging, 1609-1623.
21515848Grabauskas, G., et al. 2012. Diabetic visceral hypersensitivity is associated with activation of mitogen-activated kinase in rat dorsal root ganglia.. Diabetes, 1743-1751.
21490210Gross, C., et al. 2012. Fragile X mental retardation protein regulates protein expression and mRNA translation of the potassium channel Kv4.2.. Journal of Neuroscience, 5693-5698.
21451053Hu, H.J., et al. 2012. Metabotropic glutamate receptor 5 regulates excitability and Kv4.2-containing K⁺ channels primarily in excitatory neurons of the spinal dorsal horn.. Journal of Neurophysiology, 3010-3021.
21329741Prüss, H., et al. 2012. Potassium channel expression in adult murine neural progenitor cells.. Neuroscience, 19-29.
21273417Lin, L., et al. 2012. AKAP79/150 impacts intrinsic excitability of hippocampal neurons through phospho-regulation of A-type K+ channel trafficking.. Journal of Neuroscience, 1323-1332.
22220205Sethi, J., et al. 2011. Kv4. 2 mediates histamine modulation of preoptic neuron activity and body temperature. . PLoS One, e29134.
21943606Sun, W., et al. 2011. DPP6 establishes the A-type K(+) current gradient critical for the regulation of dendritic excitability in CA1 hippocampal neurons.. Neuron, 1102-1115.
21507952Cheng, L., et al. 2011. Cortactin is required for N-cadherin regulation of Kv1.5 channel function.. The Journal of Biological Chemistry, 20478-20489.
21451062Guan, D., et al. 2011. Postnatal development of A-type and Kv1- and Kv2-mediated potassium channel currents in neocortical pyramidal neurons.. Journal of Neurophysiology, 2976-88.
19913943Haberman, R.P., et al. 2011. Prominent hippocampal CA3 gene expression profile in neurocognitive aging.. Neurobiology of Aging, 1678-1692.
20943905Norris, A.J., et al. 2010. Interdependent roles for accessory KChIP2, KChIP3, and KChIP4 subunits in the generation of Kv4-encoded IA channels in cortical pyramidal neurons.. Journal of Neuroscience, 13644-13655.
20849929Dabrowska, J., et al. 2010. Expression and distribution of Kv4 potassium channel subunits and potassium channel interacting proteins in subpopulations of interneurons in the basolateral amygdala.. Neuroscience, 721-33.
20849929Dabrowska, J., et al. 2010. Expression and distribution of Kv4 potassium channel subunits and potassium channel interacting proteins in subpopulations of interneurons in the basolateral amygdala.. Neuroscience, 721-33.
20709747Foeger, N.C., et al. 2010. Co-assembly of Kv4 {alpha} subunits with K+ channel-interacting protein 2 stabilizes protein expression and promotes surface retention of channel complexes.. The Journal of Biological Chemistry, 33413-33422.
20650612Bealer, S.L., et al. 2010. Autonomic and cellular mechanisms mediating detrimental cardiac effects of status epilepticus.. Epilepsy Research, 66-73.
20381592Min, M.Y., et al. 2010. Roles of A-type potassium currents in tuning spike frequency and integrating synaptic transmission in noradrenergic neurons of the A7 catecholamine cell group in rats.. Neuroscience, 633-645.
20371829Norris, A.J., et al. 2010. Molecular dissection of I(A) in cortical pyramidal neurons reveals three distinct components encoded by Kv4.2, Kv4.3, and Kv1.4 alpha-subunits.. Journal of Neuroscience, 5092-5101.
20045463Lin, L., et al. 2010. KChIP4a regulates Kv4.2 channel trafficking through PKA phosphorylation.. Molecular and Cellular Neuroscience, 315-25.
19850106Mulholland, P.J., et al. 2010. Inhibition of glutamate transporters couples to Kv4.2 dephosphorylation through activation of extrasynaptic NMDA receptors.. Neuroscience, 130-137.
19713751Marionneau, C., et al. 2009. Proteomic analyses of native brain K(V)4.2 channel complexes.. Channels (Austin)., 287-297.
19703524Qu, J., et al. 2009. The development of Kv4.2 expression in the retina.. Neuroscience Letters, 209-213.
19668710Phuket, T.R., et al. 2009. Kv4 Channels Underlie the Subthreshold-Operating A-type K-current in Nociceptive Dorsal Root Ganglion Neurons.. Frontiers in Molecular Neuroscience, 3.
19596445Aronica, E., et al. 2009. Expression and localization of voltage dependent potassium channel Kv4.2 in epilepsy associated focal lesions.. Neurobiology of Disease, 81-95.
19441798Seikel, E., et al. 2009. Convergent modulation of Kv4.2 channel alpha subunits by structurally distinct DPPX and KChIP auxiliary subunits.. Biochemistry, 5721-5730.
19377470Lewis, T.L., et al. 2009. Myosin-dependent targeting of transmembrane proteins to neuronal dendrites.. Nature Neuroscience, 568-576.
19185023Harvey, M., et al. 2009. PPTX, a pentraxin domain-containing protein, interacts with the T1 domain of K v 4.. Journal of Neuroscience Research, 1841-1847.
19022416Klemmer, P., et al. 2009. Proteomics analysis of immuno-precipitated synaptic protein complexes.. Journal of Proteomics, 82-90.
19038222Jung, S.C., et al. 2008. Rapid, bidirectional remodeling of synaptic NMDA receptor subunit composition by A-type K+ channel activity in hippocampal CA1 pyramidal neurons.. Neuron, 657-671.
18987196Day, M., et al. 2008. Differential excitability and modulation of striatal medium spiny neuron dendrites.. Journal of Neuroscience, 11603-11614.
18978958Clark, B.D., et al. 2008. DPP6 Localization in Brain Supports Function as a Kv4 Channel Associated Protein.. Frontiers in Molecular Neuroscience, 8.
18727953Monaghan, M.M., et al. 2008. Altered expression and localization of hippocampal A-type potassium channel subunits in the pilocarpine-induced model of temporal lobe epilepsy.. Neuroscience, 550-562.
18657617Shin, M., et al. 2008. Mislocalization of h channel subunits underlies h channelopathy in temporal lobe epilepsy.. Neurobiology of Disease, 26-36.
18650329Hammond, R.S., et al. 2008. Protein kinase a mediates activity-dependent Kv4.2 channel trafficking.. Journal of Neuroscience, 7513-7519.
18276729Amarillo, Y., et al. 2008. Ternary Kv4.2 channels recapitulate voltage-dependent inactivation kinetics of A-type K+ channels in cerebellar granule neurons.. The Journal of Physiology, 2093-2106.
17635915Gardoni, F., et al. 2007. SAP97 directs the localization of Kv4. 2 to spines in hippocampal neurons: regulation by CaMKII. . Journal of Biological Chemistry, 28691-28699.
17582333Kim, J., et al. 2007. Regulation of dendritic excitability by activity-dependent trafficking of the A-type K+ channel subunit Kv4.2 in hippocampal neurons.. Neuron, 933-947.
17185748Vacher, H., et al. 2007. Regulation of Kv1 channel trafficking by the mamba snake neurotoxin dendrotoxin K.. The FASEB Journal, 906-914.
17122053Burkhalter, A., et al. 2006. Differential expression of I(A) channel subunits Kv4.2 and Kv4.3 in mouse visual cortical neurons and synapses.. Journal of Neuroscience, 12274-82.
17122053Burkhalter, A., et al. 2006. Differential expression of I(A) channel subunits Kv4.2 and Kv4.3 in mouse visual cortical neurons and synapses.. Journal of Neuroscience, 12274-82.
17122038Menegola, M., et al. 2006. Unanticipated region- and cell-specific downregulation of individual KChIP auxiliary subunit isotypes in Kv4.2 knock-out mouse brain.. Journal of Neuroscience, 2137-42.

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