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Products: Primary Antibodies

Anti-SAPAP2 Antibody (N459/84)

NeuroMab Logo from NeuroMab

 Datasheet

PRODUCT OPTIONS

Brand Catalog # Option Volume Concentration Price
Brand
NeuroMab Logo
Catalog #
75-467
Option
Purified
Volume
100 µL
Concentration
1 mg/mL
Price
$275.00
Brand
NeuroMab Logo
Catalog #
73-467
Option
TC Supernatant
Volume
5 mL
Concentration
Lot dependent
Price
$275.00

Validation Images


Product Details

Antibody Type:

Monoclonal

Host Species:

Mouse

Antibody Isotype:

IgG1

Species Reactivity:

Human Mouse Rat

Applications:
WB Western Blot
IHC Immunohistochemistry
ICC Immunocytochemistry
IP Immunoprecipitation
AT Array Tomography
EM Electron Microscopy
CHIP Chromatin Immunoprecipitation
DB Dot Blot

IHC WB

Target Description:

SAPAP2 (also known as Disks large-associated protein 2, DAP-2, or DLGAP2) is a member of the SAPAP or DLGAP family of proteins. SAPAP2 is part of the scaffold in neuronal cells of the brain and is a component of the postsynaptic complex. SAPAP2 acts as an adaptor protein that binds synaptic scaffold proteins, cytoskeletal proteins and signaling proteins including PSD-95. Diseases associated with SAPAP2 are autism spectrum disorder and several cancer types.

Immunogen:

Fusion protein amino acids 76-244 (N-terminus) of rat SAPAP2 (also known as SAP90/PSD-95-associated protein 2, PSD-95/SAP90-binding protein 2, Disks large-associated protein 2, Dlgap2, DAP-2 and Dap2, accession number P97837) Mouse: 95% identity (160/169 amino acids identical)
Human: 82% identity (138/169 amino acids identical)
50% identity with SAPAP1 and other SAPAPs

Protein Name(s):

SAPAP2 (SAP90/PSD-95- associated protein 2) (PSD-95/SAP90-binding protein 2) (Disks large-associated protein 2,) (Dlgap2) (DAP-2)

Gene Name(s):

Dlgap2 Dap2


Antibody Validation and Application Notes


This antibody has been validated using the following assays:
Western Blot:

This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.

Immunocytochemistry:

This antibody shows the expected staining pattern when used to stain COS cells overexpressing target.

Immunohistochemistry:
This antibody shows the expected immunoperoxidase-diaminobenzidine / immunofluorescence staining pattern when used to stain brain sections.

Molecular Weight:

110 kDa


Quality Control


The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.

Each new lot of this antibody is tested to confirm that it shows the expected immunoperoxidase-diaminobenzidine / immunofluorescence staining pattern when used to stain brain sections.