Human Mouse Rat
SAPAP2 (also known as Disks large-associated protein 2, DAP-2, or DLGAP2) is a member of the SAPAP or DLGAP family of proteins. SAPAP2 is part of the scaffold in neuronal cells of the brain and is a component of the postsynaptic complex. SAPAP2 acts as an adaptor protein that binds synaptic scaffold proteins, cytoskeletal proteins and signaling proteins including PSD-95. Diseases associated with SAPAP2 are autism spectrum disorder and several cancer types.
Fusion protein amino acids 76-244 (N-terminus) of rat SAPAP2 (also known as SAP90/PSD-95-associated protein 2, PSD-95/SAP90-binding protein 2, Disks large-associated protein 2, Dlgap2, DAP-2 and Dap2, accession number P97837)
Mouse: 95% identity (160/169 amino acids identical)
Human: 82% identity (138/169 amino acids identical)
50% identity with SAPAP1 and other SAPAPs
SAPAP2 (SAP90/PSD-95- associated protein 2) (PSD-95/SAP90-binding protein 2) (Disks large-associated protein 2,) (Dlgap2) (DAP-2)
Antibody Validation and Application Notes
This antibody has been validated using the following assays:
This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.
This antibody shows the expected staining pattern when used to stain COS cells overexpressing target.
The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.
Each new lot of this antibody is tested to confirm that it shows the expected immunoperoxidase-diaminobenzidine / immunofluorescence staining pattern when used to stain brain sections.