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Products: Primary Antibodies

Anti-Kv4.3 potassium channel subunit Antibody (K75/30)

NeuroMab Logo from NeuroMab

 Datasheet

PRODUCT OPTIONS

Brand Catalog # Option Volume Concentration Price
Brand
NeuroMab Logo
Catalog #
75-504
Option
Purified
Volume
100 µL
Concentration
1 mg/mL
Price
$275.00
Brand
NeuroMab Logo
Catalog #
73-504
Option
TC Supernatant
Volume
5 mL
Concentration
Lot dependent
Price
$275.00

Product Details

Antibody Type:

Monoclonal

Host Species:

Mouse

Antibody Isotype:

IgG2a

Species Reactivity:

Human Mouse Rat

Applications:
WB Western Blot
IHC Immunohistochemistry
ICC Immunocytochemistry
IP Immunoprecipitation
AT Array Tomography
EM Electron Microscopy
CHIP Chromatin Immunoprecipitation
DB Dot Blot

ICC IHC WB

Target Description:

Potassium voltage-gated channel subfamily D member 3 or Kv4.3 potassium channel subunit is encoded by the gene KCND3. Kv4.3 is an alpha subunit of the voltage-gated potassium channel (Shal) family and mediates transmembrane potassium transport in excitable membranes. Kv4.3 is an integral membrane protein that combines to form tetramers. Kv4.3 is detected in the heart and brain. Diseases associated with this gene include Spinocerebellar Ataxia 19 and Brugada Syndrome.

Immunogen:

Fusion protein amino acids 415-636 (cytoplasmic C- terminus) of rat Kv4.3 (also known as Potassium voltage-gated channel subfamily D member 3 and Kcnd3, accession number Q62897)

Human: 99% identity (221/222 amino acids identical)
Mouse: 99% identity (220/222 amino acids identical)
>40% identity with Kv4.2 and Kv4.1 potassium channel subunits

Cross Reactivity:

Does not cross-react with Kv4.2

Protein Name(s):

Potassium voltage-gated channel subfamily D member 3 (Voltage-gated potassium channel subunit Kv4.3)

Gene Name(s):

Kcnd3


Antibody Validation and Application Notes


This antibody has been validated using the following assays:
Western Blot:

This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.

Immunocytochemistry:

This antibody shows the expected staining pattern when used to stain COS cells overexpressing target.

Immunohistochemistry:
This antibody shows the expected immunoperoxidase-diaminobenzidine / immunofluorescence staining pattern when used to stain brain sections.

Molecular Weight:

70 kDa


Quality Control


The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.

Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.


Citations and References

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