Anti-Slc18a2/VMAT2 Antibody (N449/73)

Name: Anti-Slc18a2/VMAT2 Antibody
Brand: NeuroMab
SKU: 75-436
Price: 308.0 USD
Availability: InStock

from NeuroMab Datasheet

Product Type

Primary Antibody

Species Reactivity

Human, Mouse, Rat

Clone

N449/73

Applications

ICC, WB

Host Species

Mouse

Format

Purified

Gene Name

Slc18a2

Molecular Weight

60 kDa

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$Immunoblot on crude membrane fractions from whole mouse (MBM) and rat (RBM) brain and from human hippocampus [HBM(H)], cerebral cortex [HBM(Cx)] and cerebellum [HBM(Cb)] probed with N449/73 (left) and N52A/42 (right) TC supe.$

Immunoblot against extracts of COS cells transiently transfected with Myc/Flag-tagged VMAT1, VMAT2, VAChT or Kv2.1 plasmid probed with N449/73 (left) or rabbit anti-Flag (right).

Immunoblot on crude membrane fractions from whole mouse (MBM) and rat (RBM) brain and from human hippocampus [HBM(H)], cerebral cortex [HBM(Cx)] and cerebellum [HBM(Cb)] probed with N449/73 (left) and N52A/42 (right) TC supe.

Volume: 100 µL

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Product Details

Target

Slc18a2 protein

Target Description

Vesicular neurotransmitter transporters sequester the transmitters into synaptic vesicles (Erickson et al., 1996). The vesicular monoamine transporter 2 (VMAT2) is responsible for catecholamine and serotonin storage in central synapses. Antibodies specific for VMAT have been used to monitor expression of the transporter during development and in aging and can be effectively used as a marker for monoamine terminals (Haycock et al., 2003; Witkovsky et al., 2005).

Format

Purified

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N449/73

Isotype

IgG2b

Applications

ICC, WB

Host Species

Mouse

Gene Name

Slc18a2

Molecular Weight

60 kDa

Antigen

Fusion protein amino acids 42-132 (first lumenal domain) of mouse Slc18a2 (also known as Synaptic vesicular amine transporter, Monoamine transporter, Solute carrier family 18 member 2, Vesicular amine transporter 2, VAT2, Svmt, Svat and Vmat2, accession number Q66L40); Rat: 82% identity (75/92 amino acids identical); Human: 73% identity (67/92 amino acids identical); 30% identity with Slc18a1/VMAT1

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2686911

Storage

Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Buffer

10mM Tris, 50mM Sodium Chloride, 0.065 % Sodium Azide pH 7.4

Conjugate

Unconjugated

Specificity

Does not cross-react with Slc18a1/VMAT1 or Slc18a3/VAChT

Quality Control

Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from opening

Synonyms

Slc18a2 protein

UniProt Details

UniProt (Human): Q05940
UniProt (Immunogen Species): Q66L40

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Anti-Slc18a2/VMAT2 Antibody (N449/73)

Anti-Slc18a2/VMAT2 Antibody
SKU: 75-436

Bulk Order Anti-Slc18a2/VMAT2 Antibody

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Anti-Slc18a2/VMAT2 Antibody (N449/73)

Anti-Slc18a2/VMAT2 Antibody SKU: 75-436

Bulk Order Anti-Slc18a2/VMAT2 Antibody

Product Details

Anti-Slc18a2/VMAT2 Antibody
SKU: 75-436