When placing orders, please note whether your facility is currently receiving packages

Products: Primary Antibodies

Anti-Potassium Chloride Cotransporter (KCC2) (Ser940) Antibody

PhosphoSolutions Logo from PhosphoSolutions

 Datasheet

Product Summary:

Our rabbit polyclonal KCC2 ser940 phospho antibody is affinity purified from pooled serum. It is excellent for use in WB and IP.

PRODUCT OPTIONS

★ Trial Size Available ★
Brand Catalog # Option Volume Concentration Price
Brand
PhosphoSolutions Logo
Catalog #
p1551-940
Option
Standard
Volume
100 µL
Concentration
Lot dependent
Price
$380.00
Brand
PhosphoSolutions Logo
Catalog #
p1551-940-025
Option
Trial Size
Volume
25 µL
Concentration
Lot dependent
Price
$119.00

Validation Images


Product Details

Antibody Type:

Polyclonal

Host Species:

Rabbit

Form:

Antigen Affinity Purified from Pooled Serum

Species Reactivity:

Mouse Rat

Applications:
WB Western Blot
IHC Immunohistochemistry
ICC Immunocytochemistry
IP Immunoprecipitation
AT Array Tomography
EM Electron Microscopy
CHIP Chromatin Immunoprecipitation
DB Dot Blot

IP WB

Target Description:

KCC2 is widely thought to be expressed exclusively in neurons where it is responsible for maintaining low intracellular chloride concentration to drive hyperpolarizing post-synaptic responses to the inhibitory neurotransmitters GABA and glycine. Serine 940 on KCC2 has been shown to be phosphorylated by PKC and has further been demonstrated to be the major site for PKC-dependent phosphorylation for full length KCC2 molecules when expressed in HEK-293 cells as phosphorylation of Ser-940 increased the cell surface stability of KCC2 in this system by decreasing it’s rate of internalization from the plasma membrane (Lee et al., 2007).

Immunogen:

Synthetic phospho-peptide corresponding to amino acid residues surrounding Thr1007 conjugated to KLH

Protein Name(s):

Potassium Chloride Cotransporter (KCC2) (Ser940)

Gene Name(s):

KCC2

Antibody Registry ID:

Standard: AB_2492213
Trial Size: AB_2492213


Antibody Validation and Application Notes

Molecular Weight:

135 kDa