Products: Primary Antibodies
PRODUCT OPTIONS
★ Trial Size Available ★Brand | Catalog # | Option | Volume | Concentration | Price | |
---|---|---|---|---|---|---|
Brand![]() |
Catalog # 1496-NR2B |
Option Standard |
Volume 100 µL |
Concentration Lot dependent |
Price $390.00 |
|
Brand![]() |
Catalog # 1496-NR2B-025 |
Option Trial Size |
Volume 25 µL |
Concentration Lot dependent |
Price $125.00 |
Product Details
Polyclonal
Rabbit
Antigen Affinity Purified from Pooled Serum
Human Mouse Rat
IHC IP WB
The ion channels activated by glutamate that are sensitive to N-methyl-Daspartate (NMDA) are designated NMDA receptors (NMDAR). The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer’s, epilepsy and ischemic neuronal cell death (Grosshans et al., 2002; Wenthold et al., 2003; Carroll and Zukin, 2002). The NMDA receptor is also one of the principal molecular targets for alcohol in the CNS (Lovinger et al., 1989; Alvestad et al., 2003; Snell et al., 1996). The rat NMDAR1 (NR1) was the first subunit of the NMDAR to be cloned and it can form NMDA activated channels when expressed in Xenopus oocytes but the currents in such channels are much smaller than those seen in situ. Channels with more physiological characteristics are produced when the NR1 subunit is combined with one or more of the NMDAR2 (NR2 A-D) subunits. Overexpression of the NR2B-subunit of the NMDA receptor has been associated with increases in learning and memory while aged, memory impaired animals have deficiencies in NR2B expression (Clayton et al., 2002a; Clayton et al., 2002b). The NMDAR is also potentiated by protein phosphorylation (Lu et al., 1999).
Fusion protein from the C-terminal region of the NR2B subunit
NMDA NR2B Subunit, GRIN, GRIN2B, GRIN2, GluN2b, nmdar2b, nmdanr2b
GRIN2B
Standard: AB_2492176
Trial Size: AB_2492176
Antibody Validation and Application Notes
180 kDa