Products: Primary Antibodies

Anti-NMDA NR2A Subunit Antibody

PhosphoSolutions Logo from PhosphoSolutions

 Datasheet

Product Summary:

We manufacture our NMDAR NR2A rabbit polyclonal antibody, affinity purified from pooled serum. Optimized in WB, IHC, and IP.

PRODUCT OPTIONS

★ Trial Size Available ★
Brand Catalog # Option Volume Concentration Price
Brand
PhosphoSolutions Logo
Catalog #
1495-NR2A
Option
Standard
Volume
100 µL
Concentration
Lot dependent
Price
$380.00
Brand
PhosphoSolutions Logo
Catalog #
1495-NR2A-025
Option
Trial Size
Volume
25 µL
Concentration
Lot dependent
Price
$119.00

Validation Images


Product Details

Antibody Type:

Polyclonal

Host Species:

Rabbit

Form:

Antigen Affinity Purified from Pooled Serum

Species Reactivity:

Human Mouse Rabbit Rat

Applications:
WB Western Blot
IHC Immunohistochemistry
ICC Immunocytochemistry
IP Immunoprecipitation
AT Array Tomography
EM Electron Microscopy
CHIP Chromatin Immunoprecipitation
DB Dot Blot

IHC IP WB

Target Description:

The ion channels activated by glutamate are typically divided into two classes. Glutamate receptors that are activated by kainate and α-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as kainate/AMPA receptors (K/AMPAR). Those that are sensitive to N-methyl-Daspartate (NMDA) are designated NMDA receptors (NMDAR). The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer’s, epilepsy and ischemic neuronal cell death (Grosshans et al., 2002; Wenthold et al., 2003; Carroll and Zukin, 2002). The NMDA receptor is also one of the principal molecular targets for alcohol in the CNS (Lovinger et al., 1989; Alvestad et al., 2003; Snell et al., 1996). The NMDAR is also potentiated by protein phosphorylation (Lu et al., 1999). The rat NMDAR1 (NR1) was the first subunit of the NMDAR to be cloned. The NR1 protein can form NMDA activated channels when expressed in Xenopus oocytes but the currents in such channels are much smaller than those seen in situ. Channels with more physiological characteristics are produced when the NR1 subunit is combined with one or more of the NMDAR2 (NR2 A-D) subunits.

Immunogen:

Fusion protein from the C-terminal region of the NR2A subunit

Protein Name(s):

NMDA NR2A Subunit GRIN, GRIN2A, GRIN2, nmdar2a

Gene Name(s):

GRIN2A

Antibody Registry ID:

Standard: AB_2492171
Trial Size: AB_2492171


Antibody Validation and Application Notes

Molecular Weight:

180 kDa