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Products: Primary Antibodies

Anti-NCC (Thiazide sensitve NaCl cotransporter) Antibody

PhosphoSolutions Logo from PhosphoSolutions

 Datasheet

Product Summary:

We manufacture our NCC thr53 rabbit polyclonal phospho antibody, affinity purified from pooled serum. Optimized in WB and IHC.

PRODUCT OPTIONS

★ Trial Size Available ★
Brand Catalog # Option Volume Concentration Price
Brand
PhosphoSolutions Logo
Catalog #
p1311-53
Option
Standard
Volume
100 µL
Concentration
Lot dependent
Price
$380.00
Brand
PhosphoSolutions Logo
Catalog #
p1311-53-025
Option
Trial Size
Volume
25 µL
Concentration
Lot dependent
Price
$119.00

Validation Images


Product Details

Antibody Type:

Polyclonal

Host Species:

Rabbit

Form:

Antigen Affinity Purified from Pooled Serum

Species Reactivity:

Human Mouse Rat

Applications:
WB Western Blot
IHC Immunohistochemistry
ICC Immunocytochemistry
IP Immunoprecipitation
AT Array Tomography
EM Electron Microscopy
CHIP Chromatin Immunoprecipitation
DB Dot Blot

IHC WB

Target Description:

The thiazide-sensitive sodium chloride cotransporter, NCC, is the major NaCl transport protein in the distal convoluted tubule (DCT) and plays an important role in maintaining blood pressure (Rosenbaek et al., 2014, Feng et al., 2015). Phosphorylation of NCC at Thr-53, Thr-58, and Ser-71 is an essential mediator of NCC function (Rosenbaek et al., 2014). NCC is constitutively cycled to the plasma membrane, and upon stimulation, it can be phosphorylated to both increase NCC activity and decrease NCC endocytosis, together increasing NaCl transport in the DCT (Feng et al., 2015).

Immunogen:

Synthetic phospho-peptide corresponding to amino acid residues surrounding Thr53 conjugated to KLH

Protein Name(s):

NCC (Thiazide sensitve NaCl cotransporter), NCC, thiazide sensitive sodium chloride cotransporter, pNCC, phospho-NCC, NaCl cotransporter, p1311-53, SLC12A3, NCC T53, 53, p-NCC, NCC-t53, phosphoncc, phospho ncc, p131153

Gene Name(s):

SLC12A3

Antibody Registry ID:

Standard: AB_2650477
Trial Size: AB_2650477


Antibody Validation and Application Notes

Molecular Weight:

160 kDa