Anti-MGL Antibody (N90/20)

Name: Anti-MGL Antibody
Brand: NeuroMab
SKU: 73-209
Price: 285.0 USD
Availability: InStock

from NeuroMab Datasheet

filler

Clonality

Monoclonal

Applications

ICC, WB

Host Species

Mouse

Gene Name

Mgll Mgl2

Molecular Weight

35 kDa

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Product Details

Target

Monoglyceride lipase (MGL) (EC 3.1.1.23) (Monoacylglycerol lipase) (MAGL)

Target Description

Monoglyceride lipase, HU-K5 , MAGL or MGL is encoded by the gene MGL. MGL acts as a serine hydrolase of the AB hydrolase superfamily. This enzyme catalyzes the conversion of monoacylglycerides to free fatty acids and glycerol and is involved in physiological processes including pain and nociperception through hydrolysis of the endocannabinoid 2-arachidonoylglycerol. (PubMed:19029917, PubMed:20079333, PubMed:21049984, PubMed:22969151, PubMed:24368842). MGL is found ubiquitously and highly expressed in adipose tissue, adrenal gland, ovary, heart, spleen, lung, skeletal muscle, kidney and brain. Diseases associated with this gene include Cannabis Dependence and Hallucinogen Dependence.

Format

TC Supernatant

Concentration

Lot dependent

Clonality

Monoclonal

Clone

N90/20

Antibody Isotype

IgG2b

Applications

ICC, WB

Host Species

Mouse

Gene Name

Mgll Mgl2

Molecular Weight

35 kDa

Antigen

Synthetic peptide amino acids 1-16 (MPEASSPRRTPQNVPY, N-terminus) of rat MGL (also known as Monoglyceride lipase, Mgll, Mgl2, HU-K5 and Lysophospholipase homolog, accession number Q8R431); Mouse: 100% identity (16/16 amino acids identical); Human: 81% identity (13/16 amino acids identical)

Species Reactivity

Mouse, Rat

Antibody Registry ID

AB_2143198

Storage

Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Conjugate

Unconjugated

Specificity

None Reported

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from opening

Synonyms

Monoglyceride lipase (MGL) (EC 3.1.1.23) (Monoacylglycerol lipase) (MAGL)

UniProt Details

UniProt (Human): Q99685
UniProt (Immunogen Species): Q8R431

Citations (1)

Iannotti FA, Silvestri C, Mazzarella E, Martella A, Calvigioni D, Piscitelli F, Ambrosino P, Petrosino S, Czifra G, Bíró T, Harkany T, Taglialatela M, Di Marzo V.. (2014), 'The endocannabinoid 2-AG controls skeletal muscle cell differentiation via CB1 receptor-dependent inhibition of Kv7 channels. .' Proceedings of the National Academy of Science of the United States of America. 10.1073/pnas.1406728111.

The FASEB Journal.

Zhang X,, Ai X,, Nakayama H, Chen B, Harris DM, Tang M, Xie Y, Szeto C, Li Y, Li Y,, Zhang H, Eckhart AD, Koch WJ, Molkentin JD, Chen X.. (2016), 'Persistent increases in Ca(2+) influx through Cav1.2 shortens action potential and causes Ca(2+) overload-induced afterdepolarizations and arrhythmias. .' Basic Research in Cardiology. 10.1007/s00395-015-0523-4.
El Gebeily G, El Khoury N, Mathieu S, Brouillette J, Fiset C.. (2015), 'Estrogen regulation of the transient outward K(+) current involves estrogen receptor α in mouse heart. .' Journal of Molecular and Cellular Cardiology. 10.1016/j.yjmcc.2015.07.013.
DiFranco M, Yu C, Quiñonez M, Vergara JL.. (2015), 'Inward rectifier potassium currents in mammalian skeletal muscle fibres. .' The Journal of Physiology. 10.1113/jphysiol.2014.283648.
Shy D, Gillet L, Ogrodnik J, Albesa M, Verkerk AO, Wolswinkel R, Rougier JS, Barc J, Essers MC, Syam N, Marsman RF, van Mil AM, Rotman S, Redon R, Bezzina CR, Remme CA, Abriel H.. (2014), 'PDZ domain-binding motif regulates cardiomyocyte compartment-specific NaV1.5 channel expression and function. .' Circulation. 10.1161/CIRCULATIONAHA.113.007852.
Luo X, Pan Z, Shan H, Xiao J, Sun X, Wang N, Lin H, Xiao L, Maguy A, Qi XY, Li Y, Gao X, Dong D, Zhang Y, Bai Y, Ai J, Sun L, Lu H, Luo XY, Wang Z, Lu Y, Yang B, Nattel S.. (2013), 'MicroRNA-26 governs profibrillatory inward-rectifier potassium current changes in atrial fibrillation. .' Journal of Clinical Investigation. 10.1172/JCI62185.
Milstein ML, Musa H, Balbuena DP, Anumonwo JM, Auerbach DS, Furspan PB, Hou L, Hu B, Schumacher SM, Vaidyanathan R, Martens JR, Jalife J.. (2012), 'Dynamic reciprocity of sodium and potassium channel expression in a macromolecular complex controls cardiac excitability and arrhythmia. .' Proceedings of the National Academy of Science of the United States of America. 10.1073/pnas.1109370109.
Cazorla M, Shegda M, Ramesh B, Harrison NL, Kellendonk C.. (2012), 'Striatal D2 receptors regulate dendritic morphology of medium spiny neurons via Kir2 channels. .' Journal of Neuroscience. 10.1523/JNEUROSCI.6056-11.2012.
Shen T, Aneas I, Sakabe N, Dirschinger RJ, Wang G, Smemo S, Westlund JM, Cheng H, Dalton N, Gu Y, Boogerd CJ, Cai CL, Peterson K, Chen J, Nobrega MA, Evans SM.. (2011), 'Tbx20 regulates a genetic program essential to adult mouse cardiomyocyte function. .' Journal of Clinical Investigation. 10.1172/JCI59472.
Cheng L, Yung A, Covarrubias M, Radice GL.. (2011), 'Cortactin is required for N-cadherin regulation of Kv1.5 channel function. .' The Journal of Biological Chemistry. 10.1074/jbc.M111.218560.
Farraj AK, Hazari MS, Haykal-Coates N, Lamb C, Winsett DW, Ge Y, Ledbetter AD, Carll AP, Bruno M, Ghio A, Costa DL.. (2011), 'ST depression, arrhythmia, vagal dominance, and reduced cardiac micro-RNA in particulate-exposed rats. .' Am J Respir Cell Mol Biol.. 10.1165/rcmb.2009-0456OC.

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Anti-MGL Antibody (N90/20)

Anti-MGL Antibody
SKU: 73-209

Product Details

Citations (1)

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Anti-MGL Antibody (N90/20)

Anti-MGL Antibody SKU: 73-209

Product Details

Citations (1)

Anti-MGL Antibody
SKU: 73-209