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Products: Primary Antibodies

Anti-MerTK Tyr749/753/754 Antibody

PhosphoSolutions Logo from PhosphoSolutions

 Datasheet

Product Summary:

We manufacture our MerTK Tyr749/753/754 rabbit polyclonal phospho antibody, which is affinity purified from pooled serum. Optimized in WB.

PRODUCT OPTIONS

★ Trial Size Available ★
Brand Catalog # Option Volume Concentration Price
Brand
PhosphoSolutions Logo
Catalog #
p186-749
Option
Standard
Volume
100 µL
Concentration
Lot dependent
Price
$380.00
Brand
PhosphoSolutions Logo
Catalog #
p186-749-025
Option
Trial Size
Volume
25 µL
Concentration
Lot dependent
Price
$119.00

Validation Images


Product Details

Antibody Type:

Polyclonal

Host Species:

Rabbit

Form:

Antigen Affinity Purified from Pooled Serum

Species Reactivity:

Human Mouse Rat

Applications:
WB Western Blot
IHC Immunohistochemistry
ICC Immunocytochemistry
IP Immunoprecipitation
AT Array Tomography
EM Electron Microscopy
CHIP Chromatin Immunoprecipitation
DB Dot Blot

WB

Target Description:

Along with Tyro-3 and Axl, Mer is a member of the TAM family of receptor tyrosine kinases (RTKs). The TAM family of RTKs regulates cell proliferation/survival, cell adhesion and migration, and blood clot stabilization processes, along with the regulation of inflammatory cytokine release (Linger et al, 2008). Additionally, the TAM family has been linked to coagulopathy and cancer when altered experimentally or genetically (Linger et al, 2008). Tri-phosphorylation of MerTK at tyr749, tyr753 and tyr754 has been identified as a key target in platelet aggregation for developing a new anti-platelet drug that decreases bleeding complications, which are current side effects of similar drugs on the market today (Zhang et al, 2013). MerTK is also seen as a therapeutic target for treating lymphoblastic leukemias, melanoma, breast, lung, colon, liver, gastric, kidney, ovarian, uterine and brain cancers (Graham et al, 1994). There has recently been increased interest in synthesizing novel ATP-competitive small molecule tyrosine kinase inhibitors to decrease tri-phosphorylation of MerTK at tyr749, tyr753, and tyr754 as a therapeutic target to treat AML (Lee-Sherick et al, 2013).

Immunogen:

Synthetic phospho-peptide corresponding to amino acid residues surrounding human MerTK Tyr749/753/754 conjugated to KLH

Protein Name(s):

MerTK Tyr749/753/754, mer, pmer, mertk, p186-749, pmertk, axl, phospho-mertk, p-mer, RTK, p-mertk, pmerkt

Gene Name(s):

MERTK

Antibody Registry ID:

Standard: AB_2744537
Trial Size: AB_2744537


Antibody Validation and Application Notes

Molecular Weight:

160 kDa