Products: Primary Antibodies

Anti-GluR1-Subunit (Ser845) Antibody

PhosphoSolutions Logo from PhosphoSolutions

 Datasheet

Product Summary:

We manufacture our GluR1 ser845 rabbit polyclonal phosphospecific antibody, affinity purified from pooled serum. Optimized in WB and IHC.

PRODUCT OPTIONS

★ Trial Size Available ★
Brand Catalog # Option Volume Concentration Price
Brand
PhosphoSolutions Logo
Catalog #
p1160-845
Option
Standard
Volume
100 µL
Concentration
Lot dependent
Price
$380.00
Brand
PhosphoSolutions Logo
Catalog #
p1160-845-025
Option
Trial Size
Volume
25 µL
Concentration
Lot dependent
Price
$119.00

Validation Images


Product Details

Antibody Type:

Polyclonal

Host Species:

Rabbit

Form:

Antigen Affinity Purified from Pooled Serum

Species Reactivity:

Mouse Rat Turtle

Applications:
WB Western Blot
IHC Immunohistochemistry
ICC Immunocytochemistry
IP Immunoprecipitation
AT Array Tomography
EM Electron Microscopy
CHIP Chromatin Immunoprecipitation
DB Dot Blot

IHC WB

Target Description:

The ion channels activated by glutamate are typically divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR) while those activated by α-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as AMPA receptors (AMPAR). The AMPAR are comprised of four distinct glutamate receptor subunits designated (GluR1-4) and they play key roles in virtually all excitatory neurotransmission in the brain (Keinänen et al., 1990; Hollmann and Heinemann, 1994). The GluR1 subunit is widely expressed throughout the nervous system. Phosphorylation of Ser-845 on GluR1 is thought to be mediated by PKA and phosphorylation of this site increases the conductance of the AMPAR (Roche et al., 1996; Banke et al., 2000). In addition, phosphorylation of this site has been linked to synaptic plasticity as well as learning and memory (Lee at al., 2003; Esteban at al., 2003).

Immunogen:

Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser845 conjugated to KLH

Protein Name(s):

GluR1-Subunit (Ser845), GluA1, Anti GluR, Anti GluR A, pglur, pampa, pglua1, s845, ser845

Gene Name(s):

GRIA1

Antibody Registry ID:

Standard: AB_2492128
Trial Size: AB_2492128


Antibody Validation and Application Notes

Molecular Weight:

100 kDa