Products: Primary Antibodies
Anti-CREB (Ser133) Antibody
from PhosphoSolutions
We manufacture our CREB ser133 rabbit polyclonal phospho antibody, affinity purified from pooled serum. Optimized in WB and IHC.
PRODUCT OPTIONS
★ Trial Size Available ★| Brand | Catalog # | Option | Volume | Concentration | Price | |
|---|---|---|---|---|---|---|
| Brand |
Catalog # p1010-133 |
Option Standard |
Volume 100 µL |
Concentration Lot dependent |
Price $380.00 |
|
| Brand |
Catalog # p1010-133-025 |
Option Trial Size |
Volume 25 µL |
Concentration Lot dependent |
Price $119.00 |
Validation Images
Product Details
Polyclonal
Rabbit
Antigen Affinity Purified from Pooled Serum
Mouse Rat
IHC WB
It is well known that the control of gene expression involves activation of protein kinase cascades that regulate transcription factors within the nucleus (Karin and Hunter, 1995). The cyclic AMP response element binding protein (CREB) is one of the best characterized stimulus-induced transcription factors (Montminy, 1997). This transcription factor is a component of intracellular signaling events that regulate a wide range of biological functions, from spermatogenesis to circadian rhythms and memory (Shaywitz and Greenberg, 1999; Silva et al., 1998). A variety of protein kinases including protein kinase A (PKA), mitogen-activated protein kinases (MAPKs), and Ca2+/calmodulin-dependent protein kinases (CaMKs) phosphorylate CREB at serine 133 (Ser-133), and phosphorylation of Ser-133 are required for CREB-mediated transcription (Johannessen et al., 2004; Kornhauser et al., 2002).
Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser133 conjugated to KLH
CREB (Ser133), p-creb, pcreb
CREB1
Standard: AB_2492066
Trial Size: AB_2492066
Antibody Validation and Application Notes
45 kDa