Products: Primary Antibodies

Anti-CREB (Ser133) Antibody

PhosphoSolutions Logo from PhosphoSolutions

 Datasheet

Product Summary:

We manufacture our CREB ser133 rabbit polyclonal phospho antibody, affinity purified from pooled serum. Optimized in WB and IHC.

PRODUCT OPTIONS

★ Trial Size Available ★
Brand Catalog # Option Volume Concentration Price
Brand
PhosphoSolutions Logo
Catalog #
p1010-133
Option
Standard
Volume
100 µL
Concentration
Lot dependent
Price
$380.00
Brand
PhosphoSolutions Logo
Catalog #
p1010-133-025
Option
Trial Size
Volume
25 µL
Concentration
Lot dependent
Price
$119.00

Validation Images


Product Details

Antibody Type:

Polyclonal

Host Species:

Rabbit

Form:

Antigen Affinity Purified from Pooled Serum

Species Reactivity:

Mouse Rat

Applications:
WB Western Blot
IHC Immunohistochemistry
ICC Immunocytochemistry
IP Immunoprecipitation
AT Array Tomography
EM Electron Microscopy
CHIP Chromatin Immunoprecipitation
DB Dot Blot

IHC WB

Target Description:

It is well known that the control of gene expression involves activation of protein kinase cascades that regulate transcription factors within the nucleus (Karin and Hunter, 1995). The cyclic AMP response element binding protein (CREB) is one of the best characterized stimulus-induced transcription factors (Montminy, 1997). This transcription factor is a component of intracellular signaling events that regulate a wide range of biological functions, from spermatogenesis to circadian rhythms and memory (Shaywitz and Greenberg, 1999; Silva et al., 1998). A variety of protein kinases including protein kinase A (PKA), mitogen-activated protein kinases (MAPKs), and Ca2+/calmodulin-dependent protein kinases (CaMKs) phosphorylate CREB at serine 133 (Ser-133), and phosphorylation of Ser-133 are required for CREB-mediated transcription (Johannessen et al., 2004; Kornhauser et al., 2002).

Immunogen:

Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser133 conjugated to KLH

Protein Name(s):

CREB (Ser133), p-creb, pcreb

Gene Name(s):

CREB1

Antibody Registry ID:

Standard: AB_2492066
Trial Size: AB_2492066


Antibody Validation and Application Notes

Molecular Weight:

45 kDa