Products: Primary Antibodies
PRODUCT OPTIONS
★ Trial Size Available ★Brand | Catalog # | Option | Volume | Concentration | Price | |
---|---|---|---|---|---|---|
Brand![]() |
Catalog # 321-COLP |
Option Standard |
Volume 100 µL |
Concentration Lot dependent |
Price $390.00 |
|
Brand![]() |
Catalog # 321-COLP-025 |
Option Trial Size |
Volume 25 µL |
Concentration Lot dependent |
Price $125.00 |
Product Details
Polyclonal
Rabbit
Antigen Affinity Purified
Human Mouse Rat
IHC WB
Collagen is an extracellular matrix protein that serves as a scaffold defining the shape and mechanical properties of many tissues and organs including skin, tendon, artery walls, fibrocartilage, bone and teeth. Type 1 collagen is the most abundant protein in mammals. Collagens are synthesized with N-terminal and C-terminal propeptides that are cleaved during maturation and secretion. After cleavage of the propeptides, the most N-terminal and C-terminal remaining sequences are known as telopeptides. Mutations in the collagen 1, alpha 1 gene (COL1A1) are known to cause osteogenesis imperfecta (aka brittle bone disease) (Byers 1989). Furthermore, mutations found in the first 90 residues of the helical region of alpha 1 collagen have been implicated in the prevention or delayed removal of the procollagen N-propeptide leading to a combined osteogenesis imperfecta and Ehlers-Danlos syndrome (EDS) phenotype (Cabral et al., 2005)
Synthetic peptide corresponding to amino acid residues specific to the collagen 1, alpha 1 propeptide conjugated to KLH
Collagen 1, alpha 1 propeptide
COL1A1
Standard: AB_2492060
Trial Size: AB_2492060
Antibody Validation and Application Notes
180 kDa