Immunoblot against extracts of COS cells transiently transfected with Myc¬Flag-tagged Cavbeta1, Cavbeta2, Cavbeta3, Cavbeta4 or untagged Kv2.1 plasmid probed with N473/86 (left) or mouse anti-Flag (right)..
Voltage-dependent L-type calcium channel subunit beta-3 or Cav ß3 is encoded by the gene CACNB3. Cavß3 is a cytoplasmic subunit of voltage-sensitive calcium channels.These channels facilitate entry of calcium ions into excitable cells are involved in a variety of calcium dependent processes, including neurotransmitter release, muscle contraction, and gene expression. Cav ß3 is expressed in brain, colon and ovary. Diseases associated with this gene include Lambert-Eaton Myasthenic Syndrome.
Fusion protein amino acids 20-149 (N-terminus) of human Cavbeta3 (also known as Voltagedependent L-type calcium channel subunit beta-3, Calcium channel voltage-dependent subunit beta 3, CAB3, CACNB3, CACNLB3 and CCHB3, accession number P54284); Rat: 100% identity (130/130 amino acids identical); Mouse: 99% identity (129/130 amino acids identical); 70% identity with Cavbeta4 and other calcium channel subunits
Human, Mouse, Rat
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