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Products: Primary Antibodies

Anti-ABCA4 (Rim Protein) Antibody

PhosphoSolutions Logo from PhosphoSolutions

 Datasheet

Product Summary:

Our mouse monoclonal ABCA4 (Rim Protein) antibody is Protein G purified. It is a great retinal photoreceptor cell marker in WB and IHC.

PRODUCT OPTIONS

★ Trial Size Available ★
Brand Catalog # Option Volume Concentration Price
Brand
PhosphoSolutions Logo
Catalog #
115-ABCA4
Option
Standard
Volume
100 µL
Concentration
Lot dependent
Price
$380.00
Brand
PhosphoSolutions Logo
Catalog #
115-ABCA4-025
Option
Trial Size
Volume
25 µL
Concentration
Lot dependent
Price
$119.00

Validation Images


Product Details

Antibody Type:

Monoclonal

Host Species:

Mouse

Form:

Protein G purified culture supernatant

Antibody Isotype:

IgG

Species Reactivity:

Bovine Human Mouse Xenopus

Applications:
WB Western Blot
IHC Immunohistochemistry
ICC Immunocytochemistry
IP Immunoprecipitation
AT Array Tomography
EM Electron Microscopy
CHIP Chromatin Immunoprecipitation
DB Dot Blot

IHC WB

Target Description:

ABCA4 (ATP-binding cassette, sub-family A (ABC1), member 4, Rim Protein) is a member of the superfamily of ATP-binding cassette (ABC) transporters (Illing et al., 1997). ABC proteins transport various molecules across extra- and intracellular membranes. This protein is a retina-specific ABC transporter with N-retinylidene-PE as a substrate. It is expressed exclusively in retina photoreceptor cells, indicating the gene product mediates transport of an essential molecule across the photoreceptor cell membrane. Mutations in this gene are found in patients diagnosed with Stargardt disease and are associated with retinitis pigmentosa-19 and age-related macular degeneration (Wiszniewski et al., 2003). Defects in ABCA4 are the cause of Stargardt disease type 1 (STGD1) (Molday et al., 2000). STGD is one of the most frequent causes of macular degeneration in childhood. Defects in ABCA4 are also known to cause fundus flavimaculatus (FFM), age-related macular degeneration type 2 (ARMD2) and cone-rod dystrophy type 3 (CORD3) (Klevering et al., 2005).

Immunogen:

Partially purified bovine 220-kDa disc rim protein

Protein Name(s):

ABCA4 (Rim Protein)

Gene Name(s):

ABCA4

Antibody Registry ID:

Standard: AB_2492034
Trial Size: AB_2492034


Antibody Validation and Application Notes

Molecular Weight:

220 kDa