Products: Primary Antibodies
PRODUCT OPTIONS
★ Trial Size Available ★Brand | Catalog # | Option | Volume | Concentration | Price | |
---|---|---|---|---|---|---|
Brand![]() |
Catalog # 115-ABCA4 |
Option Standard |
Volume 100 µL |
Concentration Lot dependent |
Price $390.00 |
|
Brand![]() |
Catalog # 115-ABCA4-025 |
Option Trial Size |
Volume 25 µL |
Concentration Lot dependent |
Price $125.00 |
Product Details
Monoclonal
Mouse
Protein G purified culture supernatant
IgG
Bovine Human Mouse Xenopus
IHC WB
ABCA4 (ATP-binding cassette, sub-family A (ABC1), member 4, Rim Protein) is a member of the superfamily of ATP-binding cassette (ABC) transporters (Illing et al., 1997). ABC proteins transport various molecules across extra- and intracellular membranes. This protein is a retina-specific ABC transporter with N-retinylidene-PE as a substrate. It is expressed exclusively in retina photoreceptor cells, indicating the gene product mediates transport of an essential molecule across the photoreceptor cell membrane. Mutations in this gene are found in patients diagnosed with Stargardt disease and are associated with retinitis pigmentosa-19 and age-related macular degeneration (Wiszniewski et al., 2003). Defects in ABCA4 are the cause of Stargardt disease type 1 (STGD1) (Molday et al., 2000). STGD is one of the most frequent causes of macular degeneration in childhood. Defects in ABCA4 are also known to cause fundus flavimaculatus (FFM), age-related macular degeneration type 2 (ARMD2) and cone-rod dystrophy type 3 (CORD3) (Klevering et al., 2005).
Partially purified bovine 220-kDa disc rim protein
ABCA4 (Rim Protein)
ABCA4
Standard: AB_2492034
Trial Size: AB_2492034
Antibody Validation and Application Notes
220 kDa