IHC IP WB
Kv4.2 K+ channel (Potassium voltage-gated channel subfamily D member 2 ) is a member of the mammalian Shal-related family and potassium voltage gated channel subunit family. Kv4 subunit family includes four Kv4 a subunits (Kv4.1, Kv4.2 and Kv4.3). However only Kv4.2 and Kv4.3 are predominantely expressed in the brain (Alfaro-Ruiz et al., 2019). Kv4.2 K+ is encoded by gene KCND2 in human. It helps to regulate the action potential's circadian rhythm firing in suprachiasmatic nucleus neurons. This process regulates the circadian rhythm of locomotor activity. It has been demonstrated that Kv 4.2 and Kv4.3 are often colocalized with pain-modulating molecules in rat spinal lamina II excitatory interneurons (Huang et al., 2005).
Synthetic peptide amino acids 209 –225 (extracellular S1-S2 loop) of rat Kv4.2 (CGSSPGHIKELPSGERY; accession number Q63881); Human: 100% identity; Mouse: 100% identity
No cross reactivity against rat Kv4.3
Kv4.2 K+ channel
TC Supernatant: AB_10672254
Antibody Validation and Application Notes
This antibody has been validated using the following assays:
This antibody has been knockout-validated in mouse brain (by Western blot and/or immunohistochemistry).
This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.
This antibody shows the expected staining pattern when used to stain COS cells overexpressing target.
The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.
Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.