Human Mouse Rat
ICC IHC WB
Gamma-aminobutyric acid receptor subunit beta-3 or GABA AR-Beta3 is encoded by the gene GABRB3. GABAA receptors are members of the Cys-loop family of ligand-gated ion channels. GABA AR-beta3 a is a subunit of the pentameric GABA receptors where GABA is the major inhibitory neurotransmitter in the vertebrate brain and mediates neuronal inhibition by binding to the GABA receptor and opening an integral chloride channel. GABA AR beta3 has been found to be expressed in retina, heart and primarily in brain at the cell junction, synapse, postsynaptic cell membrane and cytoplasmic vesicle membrane. This gene may be associated with the pathogenesis of several disorders including epilepsy and autism, childhood absence epilepsy 5 and early infantile epileptic encephalopathy 43.
Fusion protein amino acids 370-433 of mouse GABA-A-R-Beta3 (also known as gamma-aminobutyric acid receptor subunit beta-3, accession number AAB60502); Rat: 100% identity (64/64 amino acids identical); Human: 85% identity (53/64 amino acids identical); Less than 40% identity with GABA-A-R-Beta1 or -Beta2
No cross-reactivity against GABA-A-R-Beta1 or –Beta2
TC Supernatant: AB_10673389
Antibody Validation and Application Notes
This antibody has been validated using the following assays:
This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.
This antibody shows the expected staining pattern when used to stain COS cells overexpressing target.
The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.
Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.