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Products: Primary Antibodies

Anti-GABA(A)R, Alpha1 Antibody (N95/35)

NeuroMab Logo from NeuroMab

 Datasheet

PRODUCT OPTIONS

★ Trial Size Available ★
Brand Catalog # Option Volume Concentration Price
Brand
NeuroMab Logo
Catalog #
75-136
Option
Purified
Volume
100 µL
Concentration
1 mg/mL
Price
$335.00
Brand
NeuroMab Logo
Catalog #
75-136-020
Option
Purified Trial-Size
Volume
20 µL
Concentration
1 mg/mL
Price
$119.00
Brand
NeuroMab Logo
Catalog #
73-136
Option
TC Supernatant
Volume
5 mL
Concentration
Lot dependent
Price
$335.00

Validation Images


Product Details

Antibody Type:

Monoclonal

Host Species:

Mouse

Antibody Isotype:

IgG2a

Species Reactivity:

Human Mouse Rat

Applications:
WB Western Blot
IHC Immunohistochemistry
ICC Immunocytochemistry
IP Immunoprecipitation
AT Array Tomography
EM Electron Microscopy
CHIP Chromatin Immunoprecipitation
DB Dot Blot

ICC IHC WB

Target Description:

GABA(A)R, Alpha1 (Gamma-aminobutyric acid receptor subunit alpha-1) makes up two of the five subunits in the membrane bound GABA A receptor, the others being two ß2 subunits and a single ?2 subunit. The receptor is a ligand gated chloride ion channel found postsynaptically and binds GABA, the major inhibitory neurotransmitter in the CNS. Mutations in GABA(A)R, Alpha1 have been linked to several types of epilepsy.

Immunogen:

Fusion protein amino acids 355-394 of mouse GABA-AR-Alpha1 (also known as gamma-aminobutyric acid receptor subunit alpha-1, accession number P62812); Rat: 100% identity (40/40 amino acids identical); Human: 100% identity (40/40 amino acids identical); Less than 50% identity with GABA-A-R-Alpha2 or -Alpha3

Cross Reactivity:

No cross-reactivity against GABA-A-R-Alpha2 or -Alpha3

Protein Name(s):

GABA(A)R, Alpha1

Gene Name(s):

GABRA1

Antibody Registry ID:

Purified: AB_2108811
Purified Trial-Size: AB_2108811
TC Supernatant: AB_10697873


Antibody Validation and Application Notes


This antibody has been validated using the following assays:
Knockout Validation:

This antibody has been knockout-validated in mouse brain (by Western blot and/or immunohistochemistry).

Western Blot:

This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.

Immunocytochemistry:

This antibody shows the expected staining pattern when used to stain COS cells overexpressing target.

Immunohistochemistry:
This antibody shows the expected immunoperoxidase-diaminobenzidine / immunofluorescence staining pattern when used to stain brain sections.

Molecular Weight:

55 kDa


Quality Control


The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.

Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.